KLF7 - KLF transcription factor 7 Gene

中文名称：KLF 转录因子 7

种属: Homo sapiens

同用名: UKLF

关于 KLF7

功能概要

该基因编码的蛋白质是类 Kruppel 转录调节因子家族的成员。该家族中的成员调节细胞增殖、分化和存活，并在 C 末端包含三个 C2H2 锌指，介导与富含 GC 位点的结合。这种蛋白质可能通过抑制胰腺 β 细胞中的胰岛素表达和分泌以及通过解除脂肪细胞中脂肪细胞因子的分泌而促进 2 型糖尿病的进展。该基因的一个假基因位于 3 号染色体的长臂上。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 8 月]

The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting Insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]