DCLK1 - doublecortin like kinase 1 Gene

中文名称：双皮质素样激酶 1

种属: Homo sapiens

同用名: CL1; DCLK; CLICK1; DCDC3A; DCAMKL1

关于 DCLK1

功能概要

该基因编码蛋白激酶超家族和双皮质素家族的成员。该基因编码的蛋白质包含两个 N 端双皮质素结构域，可结合微管并调节微管聚合，一个 C 端丝氨酸/苏氨酸蛋白激酶结构域，与 Ca2+/钙调蛋白依赖性蛋白激酶具有显着同源性，以及一个丝氨酸/双皮质素和蛋白激酶结构域之间富含脯氨酸的结构域，介导多种蛋白质-蛋白质相互作用。编码蛋白的微管聚合活性与其蛋白激酶活性无关。编码的蛋白质参与几种不同的细胞过程，包括神经元迁移、逆行运输、神经元凋亡和神经发生。该基因受脑源性神经营养因子上调，并与记忆和一般认知能力相关。已经报道了由两个替代启动子使用和替代剪接产生的多个转录变体，但尚未定义某些变体的全长性质和生物学有效性。这些变体编码不同的同种型，它们的表达方式不同并且具有不同的激酶活性。[RefSeq 提供，2010 年 9 月]

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal Apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]