2. Gene
  3. TNFSF8 - TNF superfamily member 8 Gene

TNFSF8 - TNF superfamily member 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TNF 超家族成员 8

种属: Homo sapiens

同用名: CD153; CD30L; CD30LG; TNLG3A

基因 ID: 944 | 基因类型: protein coding

关于 TNFSF8

Cytogenetic location: 9q32-q33.1 Genomic coordinates (GRCh38): 9:114,893,343-114,930,595 (from NCBI)

This gene has 3 transcripts (splice variants) and 118 orthologues. Biased expression in lymph node (RPKM 9.3), appendix (RPKM 6.6) and 11 other tissues.

功能概要

该基因编码的蛋白质是一种属于肿瘤坏死因子 (TNF) 配体家族的细胞因子。这种细胞因子是 TNFRSF8/CD30 的配体，TNFRSF8/CD30 是一种细胞表面抗原，也是霍奇金淋巴瘤和相关血液恶性肿瘤的标志物。在 B 细胞表面表达的这种细胞因子的参与在调节 Ig 类别转换中起着抑制作用。该细胞因子显示可增强某些淋巴瘤细胞系的细胞增殖，同时诱导细胞死亡并减少其他淋巴瘤细胞系的细胞增殖。这种细胞因子对不同 CD30+ 淋巴瘤细胞系的多效性生物学活性可能在霍奇金淋巴瘤和一些非霍奇金淋巴瘤中发挥病理生理作用。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2011 年 11 月]

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

TNFSF8 基因产物(2)

mRNA Protein Name
NM_001244.4 NP_001235.1 tumor necrosis factor ligand superfamily member 8 isoform 1
NM_001252290.1 NP_001239219.1 tumor necrosis factor ligand superfamily member 8 isoform 2

TNFSF8 蛋白结构

TNF

TNF: TNF(Tumour Necrosis Factor) family (113 - 229)

  • 0
  • 100
  • 200
  • 234 a.a.
蛋白主名 其他名称

tumor necrosis factor ligand superfamily member 8

CD153 antigen

重组 TNFSF8 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76224 CD30 Ligand/TNFSF8 Protein, Human (HEK293) P32971 (Q63-D234) ≥95%
HY-P76225 CD30 Ligand/TNFSF8 Protein, Human (HEK293, hFc) P32971 (Q63-D234) ≥95%
HY-P78405 CD30 Ligand/TNFSF8 Protein, Human (HEK293, mFc) P32971 (Q63-D234) ≥95%
HY-P700036AF Animal-Free CD30 Ligand/TNFSF8 Protein, Human (His) P32971 (Q63-D234) ≥95%
HY-P700434 CD30 Ligand/TNFSF8 Protein, Human (HEK293, N-His) P32971 (Q63-D234) ≥95%

关联疾病

疾病名称 别名
Anaplastic Large Cell Lymphoma

Alcl

Cd30 Positive Anaplastic Large Cell Lymphoma

Ki-1 Positive Anaplastic Large Cell Lymphoma

Primary Systemic Alcl

Sacl

Ki-1+ Anaplastic Large Cell Lymphoma
Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma

Hodgkin Disease

Hodgkin'S Lymphoma

Hodgkins Lymphoma

Classic Hodgkin Lymphoma

CHL

Hodgkin Lymphoma, Susceptibility To

Hl

Hodgkin'S Sarcoma

Stage I Subdiaphragmatic Hodgkin Lymphoma

Stage Ii Subdiaphragmatic Hodgkin Lymphoma

Lymphoma, Hodgkin'S

Classic Hodgkin Disease

Hodgkin'S Disease

Lymphoma, Hodgkin, Susceptibility To

Hodgkin'S Disease Of Intrapelvic Lymph Nodes

Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

Malignant Lymphogranuloma

Malignant Lymphogranulomatosis

Malignant Hodgkin Lymphoma

Classical Hodgkin Lymphoma, Type Not Specified
Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos
Spastic Diplegia

Diplegic Infantile Cerebral Palsy

Little'S Disease

Cerebral Palsy

Cerebral Spastic Infantile Paralysis

Infantile Diplegic Cerebral Palsy

Infantile Spastic Cerebral Palsy

Littles Disease

Spastic Cerebral Palsy
Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma
Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14829 TNFSF8 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TNFSF8 MGD MGI:88328
Bos taurus TNFSF8 VGNC VGNC:36177
Rattus norvegicus TNFSF8 RGD RGD:1590403
Canis familiaris TNFSF8 VGNC VGNC:47673
Felis catus TNFSF8 VGNC VGNC:102999
Macaca fascicularis TNFSF8 NCBI NCBI:102143966
Others TNFSF8 NCBI
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