2. Gene
  3. CHST10 - carbohydrate sulfotransferase 10 Gene

CHST10 - carbohydrate sulfotransferase 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：碳水化合物磺基转移酶 10

种属: Homo sapiens

同用名: HNK1ST; HNK-1ST

基因 ID: 9486 | 基因类型: protein coding

关于 CHST10

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:100,391,860-100,417,668 (from NCBI)

This gene has 12 transcripts (splice variants), 201 orthologues and 6 paralogues. Broad expression in brain (RPKM 10.4), endometrium (RPKM 4.2) and 21 other tissues.

功能概要

这种由该基因编码的蛋白质将硫酸盐转移到蛋白质和脂质连接的寡糖的末端葡糖醛酸的 C-3 羟基。这种蛋白质首先被鉴定为作用于人类自然杀伤 1 (HNK-1) 聚糖的磺基转移酶； HNK-1 是一种参与神经发育和突触可塑性的碳水化合物。[RefSeq 提供，2011 年 2 月]

This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein- and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic plasticity.[provided by RefSeq, Feb 2011]

CHST10 基因产物(1)

mRNA Protein Name
NM_004854.5 NP_004845.1 carbohydrate sulfotransferase 10 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables sulfotransferase activity IDA
IDA: 通过直接分析推断
23269668 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in androgen metabolic process IDA
IDA: 通过直接分析推断
23269668 GOA
involved in estrogen metabolic process IDA
IDA: 通过直接分析推断
23269668 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CHST10 蛋白结构

Sulfotransfer_2

Sulfotransfer_2: Sulfotransferase family (112 - 349)

  • 0
  • 100
  • 200
  • 300
  • 356 a.a.
蛋白主名 其他名称

carbohydrate sulfotransferase 10

HNK-1 sulfotransferase

关联疾病

疾病名称 别名
Retinitis Pigmentosa 33

RP33

Retinitis Pigmentosa, Type 33
Walker-Warburg Syndrome

Hard Syndrome

Walker-Warburg Congenital Muscular Dystrophy

Cerebroocular Dysplasia-Muscular Dystrophy Syndrome

Cod-Md Syndrome

Chemke Syndrome

Hydrocephalus, Agyria And Retinal Dysplasia

Cerebroocular Dysgenesis

Cerebroocular Dysplasia Muscular Dystrophy Syndrome

Hard +/- E Syndrome

Pagon Syndrome

Warburg Syndrome

Hydrocephalus, Agyria, And Retinal Dysplasia

Mddga

Muscular Dystrophy-Dystroglycanopathy , Type A

Muscular Dystrophy-Dystroglycanopathy [With Brain And Eye Anomalies], Type A

Hydrocephalus-Agyria-Retinal Dysplasia Syndrome

Wws

Dystrophy, Muscular, Dystroglycanopathy, Type A
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02682 CHST10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CHST10 MGD MGI:2138283
Canis familiaris CHST10 VGNC VGNC:39250
Felis catus CHST10 VGNC VGNC:60888
Bos taurus CHST10 VGNC VGNC:27338
Rattus norvegicus CHST10 RGD RGD:621216
Macaca mulatta CHST10 VGNC VGNC:71052
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