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Gossypolone 是一种 RNA 结合蛋白 Musashi-1 抑制剂，Ki 为 12 nM。Gossypolone 破坏 Musashi-numb RNA 相互作用，直接结合 MSI1 蛋白的 RBD1。Gossypolone 可用于癌症研究。

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Gossypolone Chemical Structure

Gossypolone Chemical Structure

CAS No. : 4547-72-2

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规格 价格 是否有货 数量
1 mg ￥2193
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Gossypolone 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gossypolone is an RNA-binding protein Musashi-1 inhibitor with a Ki of 12 nM. Gossypolone disrupts the Musashi-numb RNA interaction and directly binds to the RBD1 of MSI1 protein. Gossypolone can be used for the research of cancer[1].

IC50 & Target

Musashi-1[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa IC50
23.3 μM
Compound: 13, gossypolone
Anticancer activity against human HeLa cells after 48 hrs by MTT assay
Anticancer activity against human HeLa cells after 48 hrs by MTT assay
[PMID: 19447525]
U-87MG ATCC IC50
26.1 μM
Compound: 13, gossypolone
Anticancer activity against human U87 cells after 48 hrs by MTT assay
Anticancer activity against human U87 cells after 48 hrs by MTT assay
[PMID: 19447525]
分子量

546.52

Formula

C30H26O10
CAS 号
性状

固体

颜色

Light yellow to brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

纯度 & 产品资料
参考文献

Gossypolone 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gossypolone4547-72-2OthersHCT-116Colon cancerMusashiRNA-binding proteinInhibitorinhibitorinhibit

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Gossypolone
目录号：
HY-119734
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