2. Apoptosis Metabolic Enzyme/Protease
  3. Glutathione Peroxidase
  4. GPX4-IN-4

GPX4-IN-4 (Compound 24) 是一种有效的 GPX4 抑制剂。GPX4-IN-4 可用于癌症的研究。

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GPX4-IN-4 Chemical Structure

GPX4-IN-4 Chemical Structure

CAS No. : 2920221-53-8

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规格 价格 是否有货 数量
5 mg ￥1960
5 - 7 周
10 mg ￥3150
5 - 7 周
25 mg ￥5950
5 - 7 周
50 mg 现货 5 - 7 周
100 mg 现货 5 - 7 周
200 mg   询价  
500 mg   询价  

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Customer Review

GPX4-IN-4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GPX4-IN-4 (Compound 24) is a potent GPX4 inhibitor. GPX4-IN-4 can be used for the research of cancer[1].

IC50 & Target

GPX4[1]
体外研究
(In Vitro)

GPX4-IN-4 (Compound 24; 0-1000 nM; 0-24 h) inhibits HT1080 cell viability in a concentration- and time- dependent manner[1].
GPX4-IN-4 (0-10 μM; 72 h) inhibits NCI-H1703 cell viability with EC50s of 0.117 μM and 4.74 μM without and with Fer-1 (HY-100579), respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GPX4-IN-4 相关抗体:

Cell Viability Assay[1]

Cell Line: HT1080 (GPX4 dependent) cells
Concentration: 0-1000 nM
Incubation Time: 0, 1.5, 3, 6 and 24 h
Result: Inhibited cell viability with EC50s of 0.85, 0.27, 0.17 and 0.09 μM at 1.5, 3, 6 and 24 h, respectively.

Cell Viability Assay[1]

Cell Line: NCI-H1703
Concentration: 0-10 μM
Incubation Time: 72 h
Result: Inhibited cell viability with EC50s of 0.117 μM and 4.74 μM without and with Fer-1, respectively.
体内研究
(In Vivo)

GPX4-IN-4 (Compound 24; 100 and 200 mg/kg; i.p.; once) 在小鼠中作用于肾脏的 GPX4 并引发 PD 标志物的表达[1]。
尽管在肿瘤组织块中观察到部分目标结合，但 GPX4-IN-4 (50 mg/kg; i.p.; daily for 20 days) 对小鼠 WSU-DLCL2 肿瘤生长没有影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID/Beige mice[1]
Dosage: 100 and 200 mg/kg
Administration: IP, once
Result: The GPX4 band was shifted. Engaged kidney GPX4 and induced PD markers.
Animal Model: SCID/Beige mice[1]
Dosage: 30 and 100 mg/kg
Administration: IP (Pharmacokinetic Analysis)
Result: PK Properties of GPX4-IN-4 (Compound 24)[1]
Dose t1/2 (h) Cmax (μg/mL) AUC (μg*h/mL)
30 (IP) 0.5 0.92 (±0.24) 1.89 (±0.17)
100 (IP) 1.7 5.31 (±0.53) 16.20 (±1.70)
分子量

460.93

Formula

C22H21ClN2O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GPX4-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPX4-IN-42920221-53-8Glutathione PeroxidaseHT1080NCI-H1703WSU-DLCL2SCID/Beige miceInhibitorinhibitorinhibit

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目录号：
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