2. Epigenetics
  3. MicroRNA
  4. hsa-let-7a-5p agomir

hsa-let-7a-5p agomir 是一种经过特殊化学修饰的miRNA模拟物，miRNA成熟链全链进行甲氧基修饰，在5'端和3'端分别有2个和4个硫代骨架修饰，并在3'端连接有高亲和性胆固醇修饰。miRNA agomir 可以模拟内源性miRNA，上调miRNA活性。与普通模拟物相比，miRNA agomir在动物实验中具有更高的稳定性和抑制效果，更易通过细胞膜、组织间隙而富集于靶细胞。

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RNA, (UGAGGUAGUAGGUUGUAUAGUU), complex with RNA, (CUAUACAACCUACUACCUCANN) (1:1) (with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification)

hsa-let-7a-5p agomir Chemical Structure

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规格 价格 是否有货 数量
5 nmol ￥1580
In-stock
20 nmol ￥3160
In-stock

* Please select Quantity before adding items.

Customer Review

Other Forms of hsa-let-7a-5p agomir:

hsa-let-7a-5p agomir 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

生物活性

hsa-let-7a-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

分子量

15089.35

miRBase编号
成熟miRNA序列

UGAGGUAGUAGGUUGUAUAGUU

茎环结构ID

hsa-let-7a-1

茎环结构序列

UGGGAUGAGGUAGUAGGUUGUAUAGUUUUAGGGUCACACCCACCACUGGGAGAUAACUAUACAAUCUACUGUCUUUCCUA

种属

Human, Mouse, Rat, Caenorhabditis elegans, Alligator mississippiensis, Anolis carolinensis, Ascaris suum, Astatotilapia burtoni, Bovine, Branchiostoma belcheri, Branchiostoma floridae, Brugia malayi, Caenorhabditis brenneri, Caenorhabditis briggsae, Caenorhabditis remanei, Callithrix jacchus, Chicken, Chrysemys picta, Columba livia, Cricetulus griseus, Cyprinus carpio, Dasypus novemcinctus, Daubentonia madagascariensis, Dog, Fugu rubripes, Gadus morhua, Goat, Guinea pig, Heligmosomoides polygyrus, Horse, Ictalurus punctatus, Lottia gigantea, Metriaclima zebra, Microcebus murinus, Monodelphis domestica, Neolamprologus brichardi, Nomascus leucogenys, Ophiophagus hannah, Oreochromis niloticus, Oryzias latipes, Otolemur garnettii, Pan paniscus, Pan troglodytes, Papio hamadryas, Parasteatoda tepidariorum, Petromyzon marinus, Pig, Pongo pygmaeus, Pristionchus pacificus, Pteropus alecto, Pundamilia nyererei, Python bivittatus, Rabbit, Rhesus monkey, Saccoglossus kowalevskii, Saimiri boliviensis, Salmo salar, Sheep, Taeniopygia guttata, Tetraodon nigroviridis, Xenopus laevis, Xenopus tropicalis, Zebrafish

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: 99.23%

COA (271 KB) LCMS (565 KB)

产品使用指南 (1538 KB)

hsa-let-7a-5p agomir 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hsa-let-7a-5p agomirMicroRNAmiRNAInhibitorinhibitorinhibit

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产品名称：
hsa-let-7a-5p agomir
目录号：
HY-R00003A
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