2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. HSP90-IN-19

HSP90-IN-19 是一种有效的热休克蛋白 90 (Hsp90) 抑制剂。HSP90-IN-19 具有有效的 Hsp90 抑制活性，IC50 值为 0.27 μM。HSP90-IN-19 可用于病毒感染、神经退行性疾病和炎症的研究。

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HSP90-IN-19 Chemical Structure

HSP90-IN-19 Chemical Structure

CAS No. : 2927442-48-4

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HSP90-IN-19 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HSP90-IN-19 is an effective heat shock protein 90 (Hsp90) inhibitor. HSP90-IN-19 has effective Hsp90 inhibitory activity with an IC50 value of 0.27 μM. HSP90-IN-19 can be used for the research of viral infection, neurodegenerative disease, and inflammation[1].

IC50 & Target

IC50: 0.27 μM (Hsp90); ＞40 μM (MCF-7); ＞40 (SW480); ＞40 μM (A549); 16.95 μM (HL60); ＞40 μM (SMMC-7721)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 40 μM
Compound: 31
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 36274275]
HL-60 IC50
16.95 μM
Compound: 31
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 36274275]
MCF7 IC50
> 40 μM
Compound: 31
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 36274275]
SMMC-7721 IC50
> 40 μM
Compound: 31
Antiproliferative activity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 36274275]
SW480 IC50
> 40 μM
Compound: 31
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 36274275]
体外研究
(In Vitro)

HSP90-IN-19 具有有效的 Hsp90 抑制活性，IC50 值为 0.27 μM[1]。
HSP90-IN-19 (40, 8, 1.6, 0.32, 0.064 μM; 48 h) 对 MCF-7、SW480、A549、HL60 和 SMMC-7721 具有抗增殖活性，IC50 值分别为＞40 μM、＞40 μM、＞40 μM、16.95 μM 和 ＞40 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HSP90-IN-19 相关抗体:
分子量

498.61

Formula

C29H38O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HSP90-IN-19 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSP90-IN-192927442-48-4HSPHeat shock proteinsheat shock protein 90 (Hsp90)viral infectionneurodegenerative diseaseinflammationInhibitorinhibitorinhibit

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目录号：
HY-152028
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