2. PROTAC
  3. PROTAC Linkers
  4. Iodo-PEG3-N3

Iodo-PEG3-N3 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。Iodo-PEG3-N3 是一种点击化学试剂。它含有 Azide 基团，可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应（CuAAc)。它还可以和含有 DBCO 或 BCN 基团的分子发生环张力驱动的炔-叠氮环加成反应 (SPAAC)。

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Iodo-PEG3-N3 Chemical Structure

Iodo-PEG3-N3 Chemical Structure

CAS No. : 936917-36-1

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规格 价格 是否有货 数量
50 mg ￥735
In-stock
100 mg ￥1363
In-stock
250 mg ￥2725
In-stock
1 g 现货 询价
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Customer Review

Iodo-PEG3-N3 相关抗体

Top Publications Citing Use of Products

查看 PROTAC Linkers 亚型特异性产品:

查看所有亚型
PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Iodo-PEG3-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Iodo-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Iodo-PEG3-N3 相关抗体:
分子量

329.14

Formula

C8H16IN3O3
CAS 号
性状

液体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥97.0%

COA (184 KB) HNMR (111 KB)

产品使用指南 (1538 KB)
参考文献

Iodo-PEG3-N3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Iodo-PEG3-N3936917-36-1PROTAC LinkersInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-130525
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