2. PROTAC
  3. Ligands for Target Protein for PROTAC
  4. Ipatasertib-NH2 dihydrochloride

Ipatasertib-NH2 dihydrochloride  (Synonyms: GDC-0068-NH2 dihydrochloride; RG7440-NH2 dihydrochloride)

目录号: HY-130988A
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摩尔计算器

Ipatasertib-NH2 dihydrochloride 是 PROTAC (INY-03-041) 靶蛋白 AKT 的配体。INY-03-041 由 Ipatasertib-NH2、一个十烃连接体和一个用于 E3 泛素连接酶的 CRBN 配体 Lenalidomide 组成。

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Ipatasertib-NH2 dihydrochloride Chemical Structure

Ipatasertib-NH2 dihydrochloride Chemical Structure

CAS No. : 1001264-73-8

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Ipatasertib-NH2 dihydrochloride 的其他形式现货产品:

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Ipatasertib-NH2 dihydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ipatasertib-NH2 dihydrochloride is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase[1].

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ipatasertib-NH2 dihydrochloride 相关抗体:
分子量

488.84

Formula

C21H28Cl3N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ipatasertib-NH2 dihydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Ipatasertib-NH21001264-73-8GDC-0068-NH2RG7440-NH2Ligands for Target Protein for PROTACTarget Protein-binding MoietyGDC-0068IpatasertibAKTlenalidomidePROTACINY-03-041Inhibitorinhibitorinhibit

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