2. Metabolic Enzyme/Protease
  3. Aminopeptidase
  4. LTA4H-IN-5

LTA4H-IN-5 (Compound H122) 是口服有效的白三烯 A4 水解酶 (LTA4H) 的抑制剂，可抑制 LTA4H 氨基肽酶和 LTA4H 水解酶，IC50 分别为 0.38 nM 和 16.93 nM。LTA4H-IN-5 在 C57 小鼠中表现出良好的药代动力学特性，并可改善大鼠模型中 DNBS 诱发的溃疡性肠炎。

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LTA4H-IN-5 Chemical Structure

LTA4H-IN-5 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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LTA4H-IN-5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LTA4H-IN-5 (Compound H122) is an orally active inhibitor for leukotriene A4 hydrolase (LTA4H), that inhibits the LTA4H aminopeptidase and LTA4H hydrolase with IC50 of 0.38 nM and 16.93 nM. LTA4H-IN-5 exhibits good pharmacokinetic characteristics in C57 mice and ameliorates the DNBS-induced ulcerative enteritis in rat models[1].

IC50 & Target[1]

LTA4H aminopeptidase

0.38 nM (IC50)

LTA4H aminopeptidase

16.93 nM (IC50)

分子量

443.26

Formula

C18H17Cl2FN4O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LTA4H-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LTA4H-IN-5AminopeptidaseC57 mouseWistar ratorally activeulcerative enteritisInhibitorinhibitorinhibit

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