2. GPCR/G Protein
  3. Leukotriene Receptor
  4. LTB4 antagonist 1

LTB4 antagonist 1 是一种甲酰胺酸化合物，是一种有效的白三烯 B4 (LTB4) 拮抗剂，IC50 为 288 nM。LTB4 antagonist 1 具有显着的抗炎特性。

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LTB4 antagonist 1 Chemical Structure

LTB4 antagonist 1 Chemical Structure

CAS No. : 2929239-84-7

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LTB4 antagonist 1 相关抗体

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LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

  • 生物活性

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生物活性

LTB4 antagonist 1, a carboxamide-acid compound, is a potent Leukotriene B4 (LTB4) antagonist with an IC50 of 288 nM. LTB4 antagonist 1 has significant anti-inflammatory properties[1].

IC50 & Target[1]

LTB4

 

体内研究
(In Vivo)

LTB4 antagonist 1 (化合物 24b; 30 mg/kg; 口服) 在大鼠角叉菜胶足足水肿模型中，给药 1 小时后具有显着的抗炎活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: The model of podal edema with carrageenan in rats[1]
Dosage: 30 mg/kg
Administration: Orally; single dose
Result: After 1 h, a significant anti-inflammatory activity was observed (percentage inhibition of the edema: 39.7%) on carrageenan compared to the control group.
After 2 h, the anti-inflammatory activity decreases sharply (16.2%).
This activity completely disappeared after 4 h under TUKEY test.
分子量

445.46

Formula

C26H23NO6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LTB4 antagonist 1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LTB4 antagonist 12929239-84-7Leukotriene Receptorcarboxamide-acidLeukotriene B4anti-inflammatorypodal edemacarrageenanInhibitorinhibitorinhibit

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产品名称：
LTB4 antagonist 1
目录号：
HY-149082
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