2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Makaluvamine A

Makaluvamine A 是 Makaluvamines 的一种。Makaluvamines 可从斐济的 Zyzzya 属海绵中分离出来，具有对拓扑异构酶 II 的抑制活性以及对 HCT-116 人结肠癌细胞的细胞毒活性。

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Makaluvamine A Chemical Structure

Makaluvamine A Chemical Structure

CAS No. : 146555-78-4

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Makaluvamine A 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Makaluvamine A is a member of Makaluvamines. Makaluvamines can be isolated from Fijian sponges of the genus Zyzzya, and possess inhibitory activity toward topoisomerase II along with cytotoxic activity against HCT-116 human colon cancer cells[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
NIH3T3 IC50
5 μM
Compound: 9
Inhibition of HIV1 env protein assessed as inhibition of env expressing african green monkey BSC1 cell fusion with mouse NIH3T3 cell expressing CXCR4 and Escherichia coli T7 after 2.5 hrs by beta galactosidase report gene assay
Inhibition of HIV1 env protein assessed as inhibition of env expressing african green monkey BSC1 cell fusion with mouse NIH3T3 cell expressing CXCR4 and Escherichia coli T7 after 2.5 hrs by beta galactosidase report gene assay
[PMID: 12027767]
分子量

201.22

Formula

C11H11N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Makaluvamine A 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Makaluvamine A146555-78-4TopoisomeraseInhibitorinhibitorinhibit

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