2. Academic Validation
  3. Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors

Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors

  • Science. 2001 Jan 5;291(5501):134-7. doi: 10.1126/science.291.5501.134.
S T Davis 1,  B G Benson,  H N Bramson,  D E Chapman,  S H Dickerson,  K M Dold,  D J Eberwein,  M Edelstein,  S V Frye,  R T Gampe Jr,  R J Griffin,  P A Harris,  A M Hassell,  W D Holmes,  R N Hunter,  V B Knick,  K Lackey,  B Lovejoy,  M J Luzzio,  D Murray,  P Parker,  W J Rocque,  L Shewchuk,  J M Veal,  D H Walker,  L F Kuyper
Affiliations

Affiliation

  • 1 Department of Cancer Biology, Glaxo Wellcome Research and Development, Research Triangle Park, NC 27709, USA. std41085@glaxowellcome.com
PMID: 11141566 DOI: 10.1126/science.291.5501.134
Abstract

Most traditional cytotoxic Anticancer agents ablate the rapidly dividing epithelium of the hair follicle and induce alopecia (hair loss). Inhibition of cyclin-dependent kinase 2 (CDK2), a positive regulator of eukaryotic cell cycle progression, may represent a therapeutic strategy for prevention of chemotherapy-induced alopecia (CIA) by arresting the cell cycle and reducing the sensitivity of the epithelium to many cell cycle-active antitumor agents. Potent small-molecule inhibitors of CDK2 were developed using structure-based methods. Topical application of these compounds in a neonatal rat model of CIA reduced hair loss at the site of application in 33 to 50% of the Animals. Thus, inhibition of CDK2 represents a potentially useful approach for the prevention of CIA in Cancer patients.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-112460
    CDK2抑制剂
    CDK
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