2. Academic Validation
  3. The discovery of RFI-641 as a potent and selective inhibitor of the respiratory syncytial virus

The discovery of RFI-641 as a potent and selective inhibitor of the respiratory syncytial virus

  • Bioorg Med Chem Lett. 2001 Apr 23;11(8):1041-4. doi: 10.1016/s0960-894x(01)00150-0.
A A Nikitenko 1,  Y E Raifeld,  T Z Wang
Affiliations

Affiliation

  • 1 Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA. nikitea@war.wyeth.com
PMID: 11327584 DOI: 10.1016/s0960-894x(01)00150-0
Abstract

The design and synthesis of a new potent and selective inhibitor of the respiratory syncytial virus are described. This compound, RFI-641, emerged from analysis of the structure-activity relationship in a series of biphenyl triazine anionic compounds possessing specific anti-RSV activity. The key synthetic step involves coupling of diaminobiphenyl 11 with two equivalents of chlorotriazine 10 under microwave conditions. RFI-641 inhibited RSV in vitro and in vivo models.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-19874
    RSV抑制剂
    RSV
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