2. Academic Validation
  3. The selective NK3 receptor agonist senktide excites a subpopulation of dopamine-sensitive neurones in the rat substantia nigra pars compacta in vitro

The selective NK3 receptor agonist senktide excites a subpopulation of dopamine-sensitive neurones in the rat substantia nigra pars compacta in vitro

  • Br J Pharmacol. 1992 Jan;105(1):3-5. doi: 10.1111/j.1476-5381.1992.tb14199.x.
K D Keegan 1,  G N Woodruff,  R D Pinnock
Affiliations

Affiliation

  • 1 Parke-Davis Neuroscience Research Centre, Addenbrookes Hospital Site, Cambridge.
PMID: 1375857 DOI: 10.1111/j.1476-5381.1992.tb14199.x
Abstract

Intra- and extracellular recordings were made from substantia nigra zona compacta neurones from an in vitro rat brain slice preparation. A subpopulation of dopamine-sensitive neurones were encountered which were potently excited by bath application of the NK3 receptor agonist, senktide. On these senktide-sensitive neurones, NK1 and NK2 receptor agonists were inactive. The excitatory action of senktide supports a role for tachykinins as putative neurotransmitters in the basal ganglia.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z