2. Academic Validation
  3. Himastatin, a new antitumor antibiotic from Streptomyces hygroscopicus. II. Isolation and characterization

Himastatin, a new antitumor antibiotic from Streptomyces hygroscopicus. II. Isolation and characterization

  • J Antibiot (Tokyo). 1990 Aug;43(8):961-6. doi: 10.7164/antibiotics.43.961.
J E Leet 1,  D R Schroeder,  B S Krishnan,  J A Matson
Affiliations

Affiliation

  • 1 Bristol-Myers Squibb Company, Pharmaceutical Research and Development Division, Wallingford, Connecticut 06492.
PMID: 2211363 DOI: 10.7164/antibiotics.43.961
Abstract

The novel antitumor Antibiotic himastatin was isolated from cultured broth of Streptomyces hygroscopicus (ATCC 53653) and purified by vacuum liquid chromatography, column chromatography, and crystallization. Degradation and spectroscopic studies have shown that himastatin contains valine, leucine, threonine, alpha-hydroxyisovaleric acid, 5-hydroxypiperazic acid and a dimeric hexahydropyrroloindole system.

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