1. Academic Validation
  2. C-terminal angiogenin peptides inhibit the biological and enzymatic activities of angiogenin

C-terminal angiogenin peptides inhibit the biological and enzymatic activities of angiogenin

  • Biochem Biophys Res Commun. 1989 Jul 14;162(1):535-43. doi: 10.1016/0006-291x(89)92030-5.
S M Rybak 1 D S Auld D K St Clair Q Z Yao J W Fett
Affiliations

Affiliation

  • 1 Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Boston, Massachusetts 02115.
Abstract

Synthetic Peptides corresponding to the C-terminal region of angiogenin (Ang) inhibit the enzymatic and biological activities of the molecule while Peptides from the N-terminal region do not affect either activity. The peptide Ang(108-121) transiently abolishes the inhibition of cell-free protein synthesis caused by angiogenin coincidentally with its cleavage of reticulocyte RNA. Several C-terminal Peptides also inhibit Nuclease activity of angiogenin when tRNA is the substrate. Furthermore, peptide Ang(108-123) significantly decreases neovascularization elicited by angiogenin in the chick chorioallantoic membrane assay.

Figures
Products