RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis

Affiliations

• 1 Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Saitama, Japan.
• 2 Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
• 3 Chemical Genetics Laboratory, RIKEN, Saitama, Japan.
• 4 Frontier Research Core for Life Sciences, University of Toyama, Toyama, Japan.
• 5 Fermentation Research Division, Astellas Research Technologies Co. Ltd., Ibaraki, Japan.