2. Academic Validation
  3. Pyrrolizidine alkaloids from Solenanthus lanatus DC. with acetylcholinesterase inhibitory activity

Pyrrolizidine alkaloids from Solenanthus lanatus DC. with acetylcholinesterase inhibitory activity

  • Nat Prod Res. 2016 Nov;30(22):2567-2574. doi: 10.1080/14786419.2015.1131984.
Houari Benamar 1 2,  Lamberto Tomassini 3,  Alessandro Venditti 3,  Abderrazak Marouf 1 4,  Malika Bennaceur 1 5,  Marcello Nicoletti 3
Affiliations

Affiliations

  • 1 a Laboratory of Biochemistry and Natural Products, Department of Biology, Faculty of Natural Sciences and Life , University of Oran 1 Ahmed Benbella , Oran , Algeria.
  • 2 b Department of Biology, Faculty of Natural Sciences and Life , University of Mostaganem Abdelhamid Ibn Badis , Mostaganem , Algeria.
  • 3 c Department of Environmental Biology , University "Sapienza" , Rome , Italy.
  • 4 d Institute of Science and Technology , Department of Natural Sciences and Life , Ctr Univ Naama , Naama , Algeria.
  • 5 e Laboratory of Research in Arid Areas, Faculty of Biological Sciences , University of Science and Technology Houari Boumediene , Algiers , Algeria.
PMID: 26735939 DOI: 10.1080/14786419.2015.1131984
Abstract

The whole plant ethanolic extract of Solenanthus lanatus was used for the isolation of acetylcholinesterase inhibitors. A new pyrrolizidine alkaloid, 7-O-angeloylechinatine N-oxide, 1, was isolated together with three known compounds of the same class (3'-O-acetylheliosupine N-oxide, 2, heliosupine N-oxide, 3, and heliosupine, 4), by bioassay-guided approach. Their structures were elucidated by spectroscopic methods. All the isolated compounds showed inhibition activity against the AChE, with IC50 0.53-0.60 mM.

Keywords

7-O-angeloylechinatine N-oxide; Boraginaceae; Solenantus lanatus; anti-AChE activity; pyrrolizidine alkaloids.

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