2. Academic Validation
  3. Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine

Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine

  • Pharmaceuticals (Basel). 2017 Mar 30;10(2):37. doi: 10.3390/ph10020037.
Andy D Weyer 1,  Sonya G Lehto 2
Affiliations

Affiliations

  • 1 Pacific University School of Physical Therapy, Hillsboro, OR 97123, USA. andy.weyer@pacificu.edu.
  • 2 One Amgen Center Dr, Thousand Oaks, CA 91320, USA. slehto@amgen.com.
PMID: 28358322 DOI: 10.3390/ph10020037
Abstract

A review. Development of pharmaceutical antagonists of transient receptor potential melastatin 8 (TRPM8) have been pursued for the treatment of chronic pain and migraine. This review focuses on the current state of this progress.

Keywords

cold analgesia; cold hyperalgesia; mechanical hyperalgesia; menthol; migraine; pain; transient receptor potential melastatin 8 (TRPM*).

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