2. Academic Validation
  3. Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer's Disease

Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer's Disease

  • ACS Nano. 2018 Feb 27;12(2):1321-1338. doi: 10.1021/acsnano.7b07625.
Qing Chen 1,  Yang Du 2,  Kai Zhang 1,  Zeyu Liang 2,  Jinquan Li 2,  Hao Yu 2,  Rong Ren 3,  Jin Feng 1,  Zhiming Jin 4,  Fangyuan Li 2 5,  Jihong Sun 6,  Min Zhou 1,  Qinggang He 3,  Xiaolian Sun 7,  Hong Zhang 1 8,  Mei Tian 1 8,  Daishun Ling 2 5
Affiliations

Affiliations

  • 1 Department of Nuclear Medicine and PET/CT Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou, Zhejiang 310009, P.R. China.
  • 2 Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University , 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P.R. China.
  • 3 College of Chemical & Biological Engineering, Zhejiang University , Hangzhou, Zhejiang 310027, P.R. China.
  • 4 Jiangsu Huayi Technology Limited Company , Changshu, Jiangsu 215522, P.R. China.
  • 5 Key Laboratory of Biomedical Engineering of the Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University , Hangzhou, Zhejiang 310058, P.R. China.
  • 6 Department of Radiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University , Hangzhou, Zhejiang 310016, P.R. China.
  • 7 Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health , Bethesda, Maryland 20892, United States.
  • 8 Collaborative Innovation Center for Brain Science, Fudan University , Shanghai 200032, P.R. China.
PMID: 29364648 DOI: 10.1021/acsnano.7b07625
Abstract

Alzheimer's disease (AD) remains an incurable disease and lacks efficient diagnostic methods. Most AD treatments have focused on Amyloid-β (Aβ) targeted therapy; however, it is time to consider the alternative theranostics due to accumulated findings of weak correlation between Aβ deposition and cognition, as well as the failures of Phase III clinical trial on Aβ targeted therapy. Recent studies have shown that the tau pathway is closely associated with clinical development of AD symptoms, which might be a potential therapeutic target. We herein construct a methylene blue (MB, a tau aggregation inhibitor) loaded nanocomposite (CeNC/IONC/MSN-T807), which not only possesses high binding affinity to hyperphosphorylated tau but also inhibits multiple key pathways of tau-associated AD pathogenesis. We demonstrate that these nanocomposites can relieve the AD symptoms by mitigating mitochondrial oxidative stress, suppressing tau hyperphosphorylation, and preventing neuronal death both in vitro and in vivo. The memory deficits of AD rats are significantly rescued upon treatment with MB loaded CeNC/IONC/MSN-T807. Our results indicate that hyperphosphorylated tau-targeted multifunctional nanocomposites could be a promising therapeutic candidate for Alzheimer's disease.

Keywords

Alzheimer’s disease; multifunctional nanocomposite; oxidative stress; synergistic effect; tauopathy.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z