Heparin sodium salt  (Synonyms: 肝素钠; Sodium heparin; Sodium heparinate)

Heparin sodium salt (Sodium heparin) is an anticoagulant which binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa. Heparin sodium salt significantly inhibits exosome-cell interactions.

Antithrombin III^[1]

Heparin 是一种强效抗凝血药，因为它能够加速抗凝血酶抑制血液凝固级联中丝氨酸蛋白酶的速度。Heparin 和结构相关的硫酸肝素是复杂的线性聚合物，由不同长度的链混合物组成，具有可变的序列。Heparin 与含有高正电荷密度互补结合位点的肽相互作用最紧密。Heparin 和硫酸肝素主要表现出线性螺旋二级结构，磺基和羧基以规定的间隔和规定的方向沿着多糖骨架显示。Heparin 类似于 DNA，因为它们都是高电荷线性聚合物，表现为聚电解质。人们认为 Heparin 主要通过与 AT III 相互作用发挥抗凝血作用，增强 AT-III 介导的对凝血因子（包括凝血酶和 Xa 因子）的抑制。Heparin 与 AT III 和凝血酶形成三元复合物，使凝血酶抑制的双分子速率常数增加 2000 倍。Heparin 主要位于与免疫反应密切相关的组织肥大细胞颗粒中。Heparin 与 FGF-2 和 FGFR-1 进行大量接触，稳定 FGF-FGFR 结合。Heparin 还与相邻 FGF-FGFR 复合物的 FGFR-1 接触，因此似乎促进了 FGFR 二聚化^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

6117(Average)

(C₁₄H₂₅NO₂₀S₃)_n.xNa

9041-08-1

固体

White to off-white

肝素钠

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Capila I, et al. Heparin-protein interactions. Angew Chem Int Ed Engl. 2002 Feb 1;41(3):391-412.  [Content Brief]

  [2]. Anurag Purushothaman, et al. Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions. J Biol Chem. 2016 Jan 22;291(4):1652-63.  [Content Brief]