2. Academic Validation
  3. Synergistic coating of Laponite swollen-layer and heparin composite for enhanced antifouling and antithrombotic performance

Synergistic coating of Laponite swollen-layer and heparin composite for enhanced antifouling and antithrombotic performance

  • Carbohydr Polym. 2025 Jan 15;348(Pt B):122875. doi: 10.1016/j.carbpol.2024.122875.
Se Youn Jang 1,  Soonjong Roh 2,  Kyungwon Seo 3,  Youngmee Jung 4,  Hai Yen Nguyen Thi 5,  Jeong F Kim 6,  Hyosung An 3,  Hojeong Jeon 7,  Il Keun Kwon 8,  Jin Yoo 9
Affiliations

Affiliations

  • 1 KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea; Biomaterials Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
  • 2 Biomaterials Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea.
  • 3 Department of Petrochemical Materials Engineering, Chonnam National University, Yeosu, 59631, Republic of Korea.
  • 4 Biomaterials Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; School of Electrical Electronic Engineering, YU-KIST Institute, Yonsei University, Seoul, 03722, Republic of Korea.
  • 5 Department of Energy and Chemical Engineering, Incheon National University, Incheon, 22012, Republic of Korea.
  • 6 Department of Chemical Engineering, KyungHee University, Yongin, 17104, Republic of Korea.
  • 7 KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea; Biomaterials Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea. Electronic address: jeonhj@kist.re.kr.
  • 8 Department of Dental Materials, School of Dentistry, Kyung Hee University, Seoul, 02447, Republic of Korea. Electronic address: Kwoni@khu.ac.kr.
  • 9 Biomaterials Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Division of Bio-Medical Science and Technology, KIST school, Korea University of Science and Technology (UST), Seoul, 02792, Republic of Korea. Electronic address: jyoo@kist.re.kr.
PMID: 39567120 DOI: 10.1016/j.carbpol.2024.122875
Abstract

When implantable medical devices come into contact with blood, acute thrombosis and inflammation often occur due to the adhesion and denaturation of plasma proteins, ultimately degrading device performance. To address this issue, we developed a gel-like coating with superhydrophilic properties, incorporating a heparin based outer layer designed to minimize foreign body reactions and enhance hemocompatibility. The coating was engineered using a layer-by-layer (LbL) assembly of poly-l-lysine (PLL), laponite (Lap), and heparin (Hep), utilizing electrostatic interactions. The successful formation of stable layers was confirmed by QCM-D analysis. The inner layer, composed of PLL/Lap multilayers, formed a gel-like structure that maintained superhydrophilicity and effectively prevented cell adhesion. The outermost PLL/Hep multilayers significantly suppressed thrombus formation by inhibiting plasma protein and red blood cell adsorption as well as platelet activation. The coating exhibited excellent stability, retaining its superhydrophilic properties and heparin functionality even after 7 days of immersion in DPBS. Additionally, in vitro hemocompatibility and cytocompatibility tests confirmed its non-toxicity and overall biocompatibility. These results highlight the potential application of this coating to various implantable medical devices, providing a robust solution for improving device performance and safety.

Keywords

Antifouling; Antithrombotic; Heparin; Laponite; Layer-by-layer; Swollen-layer.

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