2. Academic Validation
  3. A histone H1-binding-aptide-based apoptosis imaging probe for monitoring tumor responses to cancer therapy

A histone H1-binding-aptide-based apoptosis imaging probe for monitoring tumor responses to cancer therapy

  • Medchemcomm. 2017 Jan 5;8(2):390-393. doi: 10.1039/c6md00696e.
Yonghyun Lee 1,  Sunghyun Kim 2,  Daejin Kim 1,  Sangyong Jon 1
Affiliations

Affiliations

  • 1 KAIST Institute for the BioCentury , Department of Biological Sciences , Korea Advanced Institute of Science and Technology , 291 Daehak-ro , Daejeon 34141 , Republic of Korea.
  • 2 Korea Institute of Ceramic Engineering and Technology , Jinju 660-031 , Korea.
PMID: 30108755 DOI: 10.1039/c6md00696e
Abstract

Here we report the feasibility of using a high-affinity histone H1-binding peptide as a potential molecular Apoptosis imaging probe. The Cy5.5-labeled peptide showed high selectivity for drug-treated apoptotic tumors compared with non-apoptotic tumors in various in vivo settings, enabling detection of tumor responses to both docetaxel chemotherapy and Herceptin antibody therapy as early as 12 hours after treatment with a high signal-to-background ratio, even at extremely low doses.

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