2. Academic Validation
  3. Diisonitrile-Mediated Reactive Oxygen Species Accumulation Leads to Bacterial Growth Inhibition

Diisonitrile-Mediated Reactive Oxygen Species Accumulation Leads to Bacterial Growth Inhibition

  • J Nat Prod. 2020 May 22;83(5):1634-1640. doi: 10.1021/acs.jnatprod.0c00125.
Mengyi Zhu 1,  Lijuan Wang 2,  Wei Zhang 1,  Zhiwen Liu 2,  Muhammad Ali 3,  Muhammad Imtiaz 4,  Jing He 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China.
  • 2 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, People's Republic of China.
  • 3 Department of Biotechnology, COMSATS University Islamabad, Abbottabad campus, Abbottabad 22060, Pakistan.
  • 4 Soil and Environmental Biotechnology Division, National Institute for Biotechnology and Genetic Engineering, Faisalabad 38000, Pakistan.
PMID: 32302148 DOI: 10.1021/acs.jnatprod.0c00125
Abstract

The diisonitrile copper chelator SF2768 biosynthesized by Streptomyces thioluteus functions as a chalkophore that transports extracellular copper into producer cells in a complexed form. It was demonstrated that the treatment of eight bacteria, including Bacillus subtilis and Acinetobacter baumannii, with SF2768 led to a moderate growth inhibition which is associated with an increased level of Reactive Oxygen Species (ROS). In addition, SF2768 and its diisonitrile analogues proved to be effective Tyrosinase inhibitors. Three new analogues, SF2768 I, K, and L, were identified by detailed spectroscopic analysis.

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