2. Academic Validation
  3. Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19

Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19

  • Trends Pharmacol Sci. 2021 Jun;42(6):431-433. doi: 10.1016/j.tips.2021.03.006.
Tahsin F Kellici 1,  Ewa S Pilka 2,  Michael J Bodkin 2
Affiliations

Affiliations

  • 1 Evotec (UK) Ltd, Abingdon, UK. Electronic address: tahsin.kellici@evotec.com.
  • 2 Evotec (UK) Ltd, Abingdon, UK.
PMID: 33867130 DOI: 10.1016/j.tips.2021.03.006
Abstract

Latest research shows that SERPINE1 overexpression has an important role in Coronavirus 2019 (COVID-19)-associated coagulopathy leading to acute respiratory distress syndrome (ARDS). However, ways to target this protein remain elusive. In this forum, we discuss recent evidence linking SERPINE1 with COVID-19-related ARDS and summarize the available data on inhibitors of this target.

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