2. Academic Validation
  3. Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylation

Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylation

  • Autophagy. 2023 Aug 31;1-15. doi: 10.1080/15548627.2023.2252265.
Zhiya Deng 1 2,  Man He 1 2,  Hongbin Hu 1,  Wenqian Zhang 1 2,  Yaoyuan Zhang 1,  Yue Ge 1 3,  Tongtong Ma 1,  Jie Wu 1,  Lulan Li 1,  Maomao Sun 1 2,  Sheng An 1 2,  Jiaxin Li 1,  Qiaobing Huang 1 2,  Shenhai Gong 1 4,  Jiaxing Zhang 1 5,  Zhongqing Chen 1,  Zhenhua Zeng 1 2
Affiliations

Affiliations

  • 1 Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
  • 2 Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
  • 3 School of Nursing, Southern Medical University, Guangzhou, Guangdong, China.
  • 4 School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
  • 5 The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China.
PMID: 37651673 DOI: 10.1080/15548627.2023.2252265
Abstract

AKI: acute kidney injury; ATP: adenosine triphosphate; BUN: blood urea nitrogen; CLP: cecal ligation and puncture; eGFR: estimated glomerular filtration rate; H&E: hematoxylin and eosin staining; LCN2/NGAL: lipocalin 2; LPS: lipopolysaccharide; LTL: lotus tetragonolobus lectin; mKeima: mitochondria-targeted Keima; mtDNA: mitochondrial DNA; PAS: periodic acid - Schiff staining; RTECs: renal tubular epithelial cells; SAKI: sepsis-induced acute kidney injury; Scr: serum creatinine; SIRT3: Sirtuin 3; TFAM: transcription factor A, mitochondrial; TMRE: tetramethylrhodamine.

Keywords

Acetylation; acute kidney injury; autophagy; critical care; post-translational modification; sepsis.

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