2. Academic Validation
  3. Antiviral activity of Vigna radiata extract against feline coronavirus in vitro

Antiviral activity of Vigna radiata extract against feline coronavirus in vitro

  • Vet Q. 2024 Dec;44(1):1-13. doi: 10.1080/01652176.2024.2349665.
Ai-Ai Chou 1,  Chung-Hui Lin 2 3 4,  Yen-Chen Chang 5,  Hui-Wen Chang 5,  Yi-Chen Lin 6,  Chia-Chen Pi 6,  Yao-Ming Kan 1,  Hao-Fen Chuang 1,  Hui-Wen Chen 1 7
Affiliations

Affiliations

  • 1 Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan.
  • 2 National Taiwan University Veterinary Hospital, National Taiwan University, Taipei, Taiwan.
  • 3 Graduate Institute of Veterinary Clinical Sciences, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan.
  • 4 TACS-alliance Research Center, Taipei, Taiwan.
  • 5 Graduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan.
  • 6 King's Ground Biotech Co., Ltd., Pingtung, Taiwan.
  • 7 Animal Resource Center, National Taiwan University, Taipei, Taiwan.
PMID: 38712855 DOI: 10.1080/01652176.2024.2349665
Abstract

Feline infectious peritonitis (FIP) is a fatal illness caused by a mutated feline coronavirus (FCoV). This disease is characterized by its complexity, resulting from systemic Infection, antibody-dependent enhancement (ADE), and challenges in accessing effective therapeutics. Extract derived from Vigna radiata (L.) R. Wilczek (VRE) exhibits various pharmacological effects, including Antiviral activity. This study aimed to investigate the Antiviral potential of VRE against FCoV, addressing the urgent need to advance the treatment of FIP. We explored the anti-FCoV activity, Antiviral mechanism, and combinational application of VRE by means of in vitro Antiviral assays. Our findings reveal that VRE effectively inhibited the cytopathic effect induced by FCoV, reduced viral proliferation, and downregulated spike protein expression. Moreover, VRE blocked FCoV in the early and late Infection stages and was effective under in vitro ADE Infection. Notably, when combined with VRE, the polymerase inhibitor GS-441524 or protease inhibitor GC376 suppressed FCoV more effectively than monotherapy. In conclusion, this study characterizes the Antiviral property of VRE against FCoV in vitro, and VRE possesses therapeutic potential for FCoV treatment.

Keywords

Feline coronavirus; GC376; GS-441524; Vigna radiata extract; antiviral; feline infectious peritonitis.

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