2. Academic Validation
  3. Synthesis and antifungal selectivity of new derivatives of amphotericin B modified at the C-13 position

Synthesis and antifungal selectivity of new derivatives of amphotericin B modified at the C-13 position

  • J Antibiot (Tokyo). 1993 Mar;46(3):486-93. doi: 10.7164/antibiotics.46.486.
A W Taylor 1,  B J Costello,  P A Hunter,  W S MacLachlan,  C T Shanks
Affiliations

Affiliation

  • 1 SmithKline Beecham Pharmaceuticals, Great Burgh, Epsom, Surrey, UK.
PMID: 8478266 DOI: 10.7164/antibiotics.46.486
Abstract

The syntheses of the first amphotericin B derivatives to be modified solely at the C-13 hemiketal position are described. Selective functionalisation at this position is facilitated by use of the allyl ester as a C-16 carboxylate protecting group on the amphotericin B nucleus. In in vitro tests all compounds showed markedly reduced haemolytic activity against mammalian erythrocytes while two of the novel 13-alkoxy derivatives retained good Antifungal activity.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z