2. Cell Cycle/DNA Damage Cytoskeleton
  3. Mps1
  4. Mps1-IN-6

Mps1-IN-6 是一种有效的 Mps1 抑制剂，IC50 值为 2.596 nM。Mps1-IN-6 显示出抗增殖活性。Mps1-IN-6 具有抗癌活性。

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Mps1-IN-6 Chemical Structure

Mps1-IN-6 Chemical Structure

CAS No. : 3043761-59-4

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Mps1-IN-6 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mps1-IN-6 is a potent Mps1 inhibitor with an IC50 value of 2.596 nM. Mps1-IN-6 shows antiproliferative activity. Mps1-IN-6 shows antitumor activity[1].

IC50 & Target

IC50: 2.596 nM (Mps1)[1]
体外研究
(In Vitro)

Mps1-IN-6 (compound 31) (0-10 µM; 72 h) 显示抗增殖活性，对于 MDA-MB-468，MCF-7, REB，MV4-11，HT-29 细胞的 IC50 值分别为 0.221, >10, >10, 0.823, >10 µM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mps1-IN-6 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MDA-MB-468, MCF-7, REB, MV4-11, HT-29 cells
Concentration: 0-10 µM
Incubation Time: 72 h
Result: Showed antiproliferative activity with IC50s of 0.221, >10, >10, 0.823, >10 µM for MDA-MB-468, MCF-7, REB, MV4-11, HT-29 cells, respectively.
体内研究
(In Vivo)

Mps1-IN-6 (30, 60 mg/kg; i.v.; once daily for 21 days) 在小鼠体内显示出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six to eight week-old female BALB/c nude mice (MDA-MB-468 mouse xenograft model)[1]
Dosage: 30, 60 mg/kg
Administration: I.v.; once daily for 21 days
Result: Inhibited the tumor growth with TGI values of 21%, 34% for 30, 60 mg/kg, respectively.
分子量

633.74

Formula

C35H39N9O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mps1-IN-6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mps1-IN-63043761-59-4Mps1Monopolar spindle 1antiproliferativeantitumorMDA-MB-468 cellsInhibitorinhibitorinhibit

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