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  4. NaPi2b-IN-3

NaPi2b-IN-3 (compound 5) 是一种有效的钠依赖转运蛋白 2b (SLC34A2, NaPi2b) 抑制剂，对人和大鼠的 NaPi2b IC50 分别为 71 nM 和 28 nM。NaPi2b-IN-3 可用于高磷血症的研究。

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NaPi2b-IN-3 Chemical Structure

NaPi2b-IN-3 Chemical Structure

CAS No. : 2227443-66-3

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NaPi2b-IN-3 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NaPi2b-IN-3 (compound 5) is a potent sodium-dependent transport protein 2b (SLC34A2, NaPi2b) inhibitor with IC50s of 71 nM and 28 nM for human NaPi2b and rat NaPi2b, respectively. NaPi2b-IN-3 can be used for researching hyperphosphatemia[1].

体内研究
(In Vivo)

NaPi2b-IN-3 (1 mg/kg for IV and 10mg/kg for PO; single dosage) exhibits good activity and moderate hydrophobicity, and systemically exposes to some extent[1].
Pharmacokinetic Parameters of NaPi2b-IN-3 in male Sprague-Dawley rats[1].

IV (1 mg/kg) PO (10 mg/kg)
AUC0-t (h·ng/mL) 834 ± 353 1090 ± 430
Cmax (ng/mL) 568 ± 261
F (%) 13.1

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats[1]
Dosage: 1 and 10 mg/kg
Administration: IV and PO; single dosage
Result: Exhibited good activity and moderate hydrophobicity and systemically exposed to some extent.
分子量

773.92

Formula

C45H51N5O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NaPi2b-IN-3 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

NaPi2b-IN-32227443-66-3OthersHyperphosphatemiaNaPi2bSprague-Dawley ratsInhibitorinhibitorinhibit

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