2. NF-κB
  3. NF-κB
  4. NF-κB-IN-9

NF-κB-IN-9 是一种靶向核因子 NF-κB 的声敏剂 (λex/λem=489/628 nm)。NF-κB-IN-9 由于分子中有两个白藜芦醇单元，而对 NF-κB 信号表现出强烈的抑制作用。NF-κB-IN-9 具有抗肿瘤活性，并对癌细胞表现出显着的声细胞毒性。NF-κB-IN-9 在小鼠移植模型中具有生物安全性。

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NF-κB-IN-9 Chemical Structure

NF-κB-IN-9 Chemical Structure

CAS No. : 3033815-24-3

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NF-κB-IN-9 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NF-κB-IN-9 is a nuclear factor kappa B (NF-κB) targeting sonosensitizer (λex/λem=489/628 nm). NF-κB-IN-9 exhibits strong inhibition on NF-κB signaling due to its two resveratrol units in one molecule. NF-κB-IN-9 has anti-tumor activity and shows remarkable sonocytotoxicity against cancer cells. NF-κB-IN-9 has biosafety in eenograft mice model.

体外研究
(In Vitro)

NF-κB-IN-9（TR2；1 nM-10 μM）在 RAW 264.7 巨噬细胞中抑制 NO 产生，EC50 值为 68.9 nm[1]。
NF-κB-IN-9（10 μM；超声处理 30 秒）抑制 MCF-7 细胞增殖并诱导细胞凋亡。NF-κB-IN-9 对 MCF-7 细胞表现出声细胞毒性，在持续 30 秒、2 分钟、5 分钟超声处理时间后，IC50 分别为 1.6 μM、0.55 μM、0.29 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NF-κB-IN-9 相关抗体:
体内研究
(In Vivo)

NF-κB-IN-9（TR2；1.5 mg/kg；静脉注射；分别在第 0 天和第 10 天）在异种移植小鼠模型中显示出抗癌功效和良好的耐受性。脑内可检测到 NF-κB-IN-9 荧光，提示 TR2 可穿透血脑屏障[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MCF-7 xenograft mouse model[1]
Dosage: 1.5 mg/kg
Administration: Intravenous injection at day 0 and 10, respectively
Result: Inhibited tumor growth with no significant decrease in body weight.
Decreased the cytokine levels in the sera of mice by 42%, indicating TR2 induced an anti-inflammatory response.
分子量

947.15

Formula

C62H50N4O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NF-κB-IN-9 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NF-κB-IN-93033815-24-3NF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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