2. Apoptosis
  3. Apoptosis
  4. Nimustine

Nimustine 是一种亚硝基脲类烷基化剂。Nimustine 诱导细胞凋亡，激活 DNA 损伤以及 MAPK 信号通路。Nimustine 具有抗癌效应，可用于癌症的研究。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Nimustine hydrochloride 通常具有更好的水溶性和稳定性。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Nimustine Chemical Structure

Nimustine Chemical Structure

CAS No. : 42471-28-3

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Nimustine 的其他形式现货产品:

Customer Review

Other Forms of Nimustine:

Nimustine 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nimustine is a nitrosourea alkylating agent. Nimustine induces cell apoptosis, and activates DNA damage response and MAPK signaling. Nimustine shows anti-cancer effects, it can be used for the research of cancer[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
SF-126 IC50
310 μM
Compound: ACNU
Cytotoxicity against human SF126 cells expressing low level of AGT assessed as cell survival after 24 hrs by CCK8 assay in presence of O6-BG
Cytotoxicity against human SF126 cells expressing low level of AGT assessed as cell survival after 24 hrs by CCK8 assay in presence of O6-BG
[PMID: 27041398]
SF-126 IC50
320 μM
Compound: ACNU
Cytotoxicity against human SF126 cells expressing low level of AGT assessed as cell survival after 24 hrs by CCK8 assay
Cytotoxicity against human SF126 cells expressing low level of AGT assessed as cell survival after 24 hrs by CCK8 assay
[PMID: 27041398]
SF-126 IC50
360 μM
Compound: ACNU
Cytotoxicity against AGT-deficient human SF126 cells assessed as reduction in cell viability pretreated with O6-BG for 2 hrs followed by addition of compound measured after 24 hrs by CCK8 assay
Cytotoxicity against AGT-deficient human SF126 cells assessed as reduction in cell viability pretreated with O6-BG for 2 hrs followed by addition of compound measured after 24 hrs by CCK8 assay
[PMID: 28197307]
SF-126 IC50
450 μM
Compound: ACNU
Cytotoxicity against AGT-deficient human SF126 cells assessed as reduction in cell viability measured after 24 hrs by CCK8 assay
Cytotoxicity against AGT-deficient human SF126 cells assessed as reduction in cell viability measured after 24 hrs by CCK8 assay
[PMID: 28197307]
U-87MG ATCC IC50
0.84 μM
Compound: Nimustine
Cytotoxicity against human U87MG cells after 72 hrs by MTT assay
Cytotoxicity against human U87MG cells after 72 hrs by MTT assay
[PMID: 20184290]
体外研究
(In Vitro)

Nimustine (50 μM; 72-120 h) causes cell death by inducing cell apoptosis[1].
Nimustine (50 μM; 24-96 h) activates the DNA damage response pathway[1].
Nimustine (50 μM; 24-120 h) activates MAPK signaling in glioma cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nimustine 相关抗体:

Apoptosis Analysis[1]

Cell Line: LN-229 cell line
Concentration: 50 μM
Incubation Time: 72-120 hours
Result: Time-dependently induced apoptosis.

Western Blot Analysis[1]

Cell Line: LN-229 and glioma cell lines
Concentration: 50 μM
Incubation Time: 24-120 hours
Result: Induced cleavage of caspase-8 and -9 and the effector caspase-3. Increased phosphorylation of ERK kinase and H2AX. Decreased phosphorylation of JNK
体内研究
(In Vivo)

Nimustine (15 four times a week and 30 mg/kg twice with an interval of 2 weeks; i.v.) effectively inhibits tumor growth and the higher dose is more effective[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C3H/HeN mice with solid FM3A tumors[2]
Dosage: 15 and 30 mg/kg
Administration: Intravenous injection; 15 (4 times a week) and 30 mg/kg (twice with an interval of 2 weeks)
Result: The intermittent large-dose injections resulted in better inhibition of tumor growth than did the fractionated small-dose injections.
Clinical Trial
分子量

272.69

Formula

C9H13ClN6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nimustine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nimustine42471-28-3Apoptosisnitrosourea alkylatingapoptosisDNA damageMAPKanti-cancerLN-229gliomamiceFM3AInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Nimustine
目录号：
HY-13703
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z