2. Apoptosis Autophagy
  3. Apoptosis Autophagy MDM-2/p53
  4. p53-MDM2-IN-5

p53-MDM2-IN-5 (compound 5a) 是一种有效的 p53-MDM2 抑制剂。p53-MDM2-IN-5 诱导细胞凋亡 (apoptosis)、自噬 (autophagy) 和 DNA 损伤。p53-MDM2-IN-5 诱导细胞周期停滞在 S 和 G2/M 期。p53-MDM2-IN-5 表现出抗肿瘤活性。

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p53-MDM2-IN-5 Chemical Structure

p53-MDM2-IN-5 Chemical Structure

CAS No. : 2750075-06-8

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p53-MDM2-IN-5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

p53-MDM2-IN-5 (compound 5a) is a potent p53-MDM2 inhibitor. p53-MDM2-IN-5 induces apoptosis, autophagy and DNA damage. p53-MDM2-IN-5 induces cell cycle arrest at S and G2/M phases. p53-MDM2-IN-5 shows anti-tumor activity[1].

体外研究
(In Vitro)

p53-MDM2-IN-5 (compound 5a) (1-5 µM; 24 h) 诱导 A549 细胞凋亡，细胞周期停滞在 S 和 G2/M 期[1]。
p53-MDM2-IN-5 (1, 5 µM; 24 h) 通过降低 SQSTM1/p62 的表达来诱导自噬[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

p53-MDM2-IN-5 相关抗体:

Cell Viability Assay[1]

Cell Line: A549, A549/CDDP, Panc-1, CFPAC-1, SJSA-1, HepG2, HCT116, HLF-1 cells
Concentration: 0-100 µM
Incubation Time: 24 h
Result: Inhibited cell growth with IC50s of 0.85, 1.43, 2.22, 1.64, 0.14, 6.23, 2.57, 18.94 µM for A549, A549/CDDP, Panc-1, CFPAC-1, SJSA-1, HepG2, HCT116, HLF-1 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 1 µM
Incubation Time: 24 h
Result: Induced cell cycle arrest at S and G2/M phases.

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 0.1, 0.5, 1 µM
Incubation Time: 24 h
Result: Induced apoptosis with the percentages of apoptotic cells of 8.1%, 11.4%, and 15.1% at 0.1, 0.5, 1 µM, respectively.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 1, 5 µM
Incubation Time: 24 h
Result: Induced autophagy by promoted the conversion of LC3B-I to LC3B-II and decreased the expression of SQSTM1/p62.
体内研究
(In Vivo)

p53-MDM2-IN-5 (6 μmol/kg; i.v.; every 3 days for 21 days) 在 A549 异种移植裸鼠模型中显示出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6–8-week-old female nude mouse (A549 xenograft nude mouse model)[1]
Dosage: 6 μmol/kg
Administration: I.v.; every 3 days for 21 days
Result: Inhibited tumor growth with low toxicity.
分子量

974.57

Formula

C33H37Cl4F2N5O6Pt
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

p53-MDM2-IN-5 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

p53-MDM2-IN-52750075-06-8ApoptosisAutophagyMDM-2/p53apoptosisautophagyA549 cellsSQSTM1/p62Inhibitorinhibitorinhibit

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