2. Anti-infection
  3. Influenza Virus
  4. PAN endonuclease-IN-2

PAN endonuclease-IN-2 (compound T-31) 是 PAN 核酸内切酶抑制剂 (IC50: 0.15 μM) 和抗病毒剂，具有广谱抗流感活性。PAN 是聚合酶-RNA 复合物的 N 端 PA 亚基和依赖性核酸内切酶 (CEN) 活性位点。PAN 通过促进 RNA 链的裂解并使聚合酶开始合成新的 RNA 分子，从而启动 RNA 复制。PAN endonuclease-IN-2 可以同时靶向流感 HA 和 RdRp 复合物，从而干扰病毒进入宿主细胞和病毒复制。

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PAN endonuclease-IN-2 Chemical Structure

PAN endonuclease-IN-2 Chemical Structure

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PAN endonuclease-IN-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PAN endonuclease-IN-2 (compound T-31) is a PAN endonuclease inhibitor (IC50: 0.15 μM) and antiviral agent with broad-spectrum anti- Influenza activity. PAN is the N-terminal PA subunit of the polymerase-RNA complex and the dependent endonuclease (CEN) active site. PAN initiates RNA replication by promoting cleavage of the RNA strand and allowing the polymerase to begin synthesizing new RNA molecules. PAN endonuclease-IN-2 targets both the influenza HA and RdRp complexes, thereby interfering with viral entry into host cells and viral replication[1].

IC50 & Target

IC50: 0.15 μM (PAN endonuclease)[1]
体外研究
(In Vitro)

PAN endonuclease-IN-2 (compound T-31) 在 MDCK 细胞中，针对流感病毒 A (H1N1/A/WSN/33) 而发挥的体外抗流感 EC50 为 0.96 μM；对其他 PR/8(H1N1)、H3N2、H5N1、H9N2、Flu B 的 EC50 分别为 4.76 μM，1.85μM，5.06μM，0.71μM，2.36μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PAN endonuclease-IN-2 相关抗体:
分子量

607.24

Formula

C25H21Br2NO7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PAN endonuclease-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAN endonuclease-IN-2Influenza VirusInfluenza A virusPA(N) endonuclease inhibitorsStructure–activity relationshipl-DOPA derivativesInhibitorinhibitorinhibit

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