2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. PARP Apoptosis
  4. PARP1-IN-14

PARP1-IN-14 (compound 19k) 是一种有效的 PARP1 抑制剂，IC50 为 0.6 ± 0.1 nM。 PARP1-IN-14 对 MDA-MB-436 (BRCA1−/−) 和 Capan-1 (BRCA2−/−) 细胞具有抗增殖作用，IC50 值低于 0.3 nM。

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PARP1-IN-14 Chemical Structure

PARP1-IN-14 Chemical Structure

CAS No. : 2098639-70-2

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PARP1-IN-14 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor, with an IC50 of 0.6 ± 0.1 nM. PARP1-IN-14 exhibits antiproliferative effect against both MDA-MB-436 (BRCA1−/−) and Capan-1 (BRCA2−/−) cells with IC50 values below 0.3 nM[1].

IC50 & Target

PARP1

0.6 ± 0.1 nM (IC50)

体外研究
(In Vitro)

PARP1-IN-14 (compound 19k) 显著抑制耐药 Capan-1 细胞的增殖 (IC50 < 0.3 nM)[1]。
PARP1-IN-14（0-1 μM，24 小时）会诱导亲代 Capan-1 (BRCA2−/−) 和耐药 Capan-1 细胞中的 DNA 损伤[1].
PARP1-IN-14（0-1 μM，0-48 小时）可诱导亲代细胞和耐药细胞的细胞周期停滞和凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PARP1-IN-14 相关抗体:
分子量

525.53

Formula

C28H24FN7O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PARP1-IN-14 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP1-IN-142098639-70-2PARPApoptosispoly ADP ribose polymerase Capan-1MDA-MB-436Inhibitorinhibitorinhibit

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产品名称：
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目录号：
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