2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. PARP Apoptosis
  4. PARP1-IN-15

PARP1-IN-15 (Compound 6) 是一种 PARP1 抑制剂。PARP1-IN-15 抑制坦聚合酶 (TNKS) 并促进 DNA 双链断裂损伤。PARP1-IN-15 诱导肿瘤细胞凋亡 (apoptosis)。PARP1-IN-15 在三阴性乳腺癌 (TNBC) 细胞和 TNBC 患者来源的类器官中具有抗癌活性。 PARP1-IN-15 可用于研究有或没有 BRCA1 突变的 TNBC。

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PARP1-IN-15 Chemical Structure

PARP1-IN-15 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

PARP1-IN-15 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PARP1-IN-15 (Compound 6) is a PARP1 inhibitor. PARP1-IN-15 inhibits tankyrase (TNKS) and facilitates DNA double-strand breaks damage. PARP1-IN-15 induces tumor cell apoptosis. PARP1-IN-15 has anti-cancer activity in triple-negative breast cancer (TNBC) cells and TNBC patient-derived organoids. PARP1-IN-15 can be used for research of TNBC with or without BRCA1 mutations[1].

分子量

264.28

Formula

C16H12N2O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PARP1-IN-15 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP1-IN-15PARPApoptosispoly ADP ribose polymerase cancertumorMDA-MB-436TNBCbreast cancerDNA damageorganoidInhibitorinhibitorinhibit

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目录号：
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