2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. PD-1/PD-L1 antagonist 1

PD-1/PD-L1 antagonist 1 (Compound A5) 是程序性细胞死亡受体 1 (PD-1) 和程序性细胞死亡配体 1 (PD-L1) 相互作用的拮抗剂，IC50 为 23.78 nM。

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PD-1/PD-L1 antagonist 1 Chemical Structure

PD-1/PD-L1 antagonist 1 Chemical Structure

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PD-1/PD-L1 antagonist 1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PD-1/PD-L1 antagonist 1 (Compound A5) is an antagonist for programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1) interaction, with an IC50 of 23.78 nM[1].

IC50 & Target

23.78 nM (PD-1/PD-L1 interaction)
体外研究
(In Vitro)

PD-1/PD-L1 antagonist 1 (0-3 μM) 剂量依赖性地抑制 Jurkat-NFAT-PD-1 细胞和 Hep3B-OS8-hPD-L1 细胞共系统中的 PD-1 和 PD-L1 相互作用，在剂量范围 3.3 μM 以内对 Jurkat 细胞没有表现出明显的细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PD-1/PD-L1 antagonist 1 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: Jurkat
Concentration: 0-30 μM
Incubation Time: 48 h
Result: Maintained the cell viability with concentration less than 3.3 μM. Reduced cell viability at 10 and 30 μM.
分子量

955.88

Formula

C52H48Cl2N6O8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PD-1/PD-L1 antagonist 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-1/PD-L1 antagonist 1PD-1/PD-L1PD-1/Programmed death-ligand 1JurkatHep3BInhibitorinhibitorinhibit

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产品名称：
PD-1/PD-L1 antagonist 1
目录号：
HY-158052
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