2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. Pizuglanstat hydrate

Pizuglanstat hydrate  (Synonyms: TAS-205)

目录号: HY-109134A
产品使用指南

摩尔计算器

Pizuglanstat hydrate（TAS-205）是一种造血前列腺素 D 合成酶（HPGDS）抑制剂。TAS-205 能在细胞基础的酶学测试和体内模型中选择性抑制前列腺素 D2（PGD2）的合成，并有效减少嗜酸性粒细胞进入鼻腔和晚期鼻塞。与孟鲁司特 (HY-13315A) 联合使用时，TAS-205 显示出显著的协同抑制效应；与非索非那定 (HY-B0801A) 联合使用时，对早期和晚期鼻塞也有一定的抑制效果。

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Pizuglanstat hydrate Chemical Structure

Pizuglanstat hydrate Chemical Structure

CAS No. : 1584160-52-0

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Pizuglanstat hydrate 的其他形式现货产品:

Other Forms of Pizuglanstat hydrate:

Pizuglanstat hydrate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pizuglanstat hydrate (TAS-205) is a hematopoietic prostaglandin D synthase (HPGDS) inhibitor. TAS-205 selectively inhibits the synthesis of prostaglandin D2 (PGD2) in cell-based enzymatic tests and in vivo models, and effectively reduces the entry of eosinophils into the nasal cavity and late-stage nasal congestion. When used in combination with montelukast (HY-13315A), TAS-205 showed a significant synergistic inhibitory effect; when used in combination with fexofenadine (HY-B0801A), it also had a certain inhibitory effect on early and late nasal congestion.

分子量

526.63

Formula

C27H38N6O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pizuglanstat hydrate 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pizuglanstat1584160-52-0TAS-205TAS205TAS 205Prostaglandin ReceptorInhibitorinhibitorinhibit

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