2. Anti-infection
  3. Bacterial
  4. Pks13-TE inhibitor 2

Pks13-TE inhibitor 2 (化合物 32) 是一种 13-硫酯酶 (Pks13-TE) 抑制剂 (IC50=1.30 μM)。Pks13-TE inhibitor 2 对活性分子敏感和耐药的 Mtb 菌株都显示出良好的抗结核活性 (MIC=0.0039-0.0078 μg/mL)。Pks13-TE inhibitor 2 可用于耐多药结核和广泛耐药结核的研究。

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Pks13-TE inhibitor 2 Chemical Structure

Pks13-TE inhibitor 2 Chemical Structure

CAS No. : 3031462-75-3

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Pks13-TE inhibitor 2 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pks13-TE inhibitor 2 (compound 32) is a 13-Thioesterase (Pks13-TE) inhibitor (IC50=1.30 μM). Pks13-TE inhibitor 2 shows good anti-tuberculosis activity against both agent-sensitive and drug-resistant Mtb strains (MIC=0.0039-0.0078 μg/mL). Pks13-TE inhibitor 2 can be used in studies of multidrug-resistant TB and extensively drug-resistant TB[1].

IC50 & Target

IC50: 1.30 µM (Pks13-TE)[1].
体外研究
(In Vitro)

Pks13-TE inhibitor 2 (0-5.43 µM; 7 days) demonstrates potent activities against DS (drug-susceptible Mtb strain)-tuberculosis)-TB and DR (drug-resistant strain of Mtb-tuberculosis)-TB strains with MIC range of 0.0039-0.0078 μg/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pks13-TE inhibitor 2 相关抗体:

Cell Viability Assay[1]

Cell Line: DS (drug-susceptible Mtb strain)-tuberculosis (V4207), MDR (multidrug-resistant strain of Mtb, resistance to isoniazid and rifampin)-tuberculosis (V2475 and KZN494), XDR (extensively drug-resistant strain of Mtb resistant to isoniazid, rifampin, levofloxacin ofloxacin, and kanamycin)-tuberculosis (TF274 and R506) strains
Concentration: 0-5.43 µM (0-2048 µg/mL)
Incubation Time: 7 days
Result: Inhibited V4207/DS Mtb strain (MIC=0.0078 µg/mL) and the MIC values for V2475/MDR, KZN494/MDR, TF274/XDR and R506/XDR Mtb strains were 0.0039 µg/mL.
分子量

377.39

Formula

C22H19NO5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pks13-TE inhibitor 2 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pks13-TE inhibitor 23031462-75-3BacterialM. tuberculosistuberculosisMDR-TBXDR-TBMtbbacterialInhibitorinhibitorinhibit

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