Animal-Free CD70 蛋白, Human (His)

As a ligand of CD27, CD70 protein is an indispensable part of T cell immune coordination and is of particular importance in antiviral responses. The CD70-CD27 pathway emerged as a key player that contributes to the generation and maintenance of T cell-mediated immune responses. Animal-Free CD70 Protein, Human (His) is the recombinant human-derived animal-FreeCD70 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free CD70 Protein, Human (His) is 155 a.a., with molecular weight of ~18.08 kDa.

CD70 是一种作为 CD27 配体的细胞因子，是 CD70-CD27 途径的组成部分，该途径在 T 细胞免疫的发展和维持中发挥着至关重要的作用，特别是在抗病毒反应中。与 CD27 结合后，CD70 会诱导共刺激 T 细胞的增殖，并放大溶细胞 T 细胞的产生，从而有助于有效的免疫反应。在结构上，CD70 形成同源三聚体，反映了其分子组织。CD70-CD27 相互作用强调了其在协调 T 细胞介导的免疫反应中的重要性，为免疫功能的调节提供了宝贵的见解。

Measure by its ability to induce IL-8 secretion in human PBMCs. The ED₅₀ for this this effect is <0.6 ng/mL.

Human

E. coli

N-His

P32970 (Q39-P193)

970  [NCBI]

QRFAQAQQQLPLESLGWDVAELQLNHTGPQQDPRLYWQGGPALGRSFLHGPELDKGQLRIHRDGIYMVHIQVTLAICSSTTASRHHPTTLAVGICSPASRISLLRLSFHQGCTIASQRLTPLARGDTLCTNLTGTLLPSRNTDETFFGVQWVRP

Approximately 18.08 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a solution containing 1X PBS, pH 8.0, trehalose.

<0.01 EU per 1 μg of the protein by the LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.