2. Gene
  3. CD70 - CD70 molecule Gene

CD70 - CD70 molecule Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CD70 分子

种属: Homo sapiens

同用名: CD27L; LPFS3; CD27-L; CD27LG; TNFSF7; TNLG8A

基因 ID: 970 | 基因类型: protein coding

关于 CD70

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,581,648-6,591,150 (from NCBI)

This gene has 3 transcripts (splice variants), 88 orthologues and is associated with 2 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白质是一种属于肿瘤坏死因子 (TNF) 配体家族的细胞因子。这种细胞因子是 TNFRSF27/CD27 的配体。它是激活的表面抗原，但不是静止的 T 和 B 淋巴细胞。它诱导共刺激 T 细胞的增殖，增强细胞溶解性 T 细胞的产生，并有助于 T 细胞活化。据报道，该细胞因子还在调节 B 细胞活化、自然杀伤细胞的细胞毒功能和免疫球蛋白合成中发挥作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

CD70 基因产物(2)

mRNA Protein Name
NM_001252.5 NP_001243.1 CD70 antigen isoform 1
NM_001330332.2 NP_001317261.1 CD70 antigen isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12324477 GOA
enables receptor ligand activity IDA
IDA: 通过直接分析推断
8387892 GOA
enables receptor ligand activity IMP
IMP: 通过突变表型推断
28011863 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in B cell mediated immunity IMP
IMP: 通过突变表型推断
28011864 GOA
involved in B cell proliferation IMP
IMP: 通过突变表型推断
28011864 GOA
involved in CD27 signaling pathway IDA
IDA: 通过直接分析推断
8387892 GOA
involved in T cell activation IDA
IDA: 通过直接分析推断
8387892 GOA
involved in T cell mediated immunity IMP
IMP: 通过突变表型推断
28011864 GOA
involved in adaptive immune memory response involving T cells and B cells IMP
IMP: 通过突变表型推断
28011863 GOA
involved in extrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
9177220 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in plasma membrane IDA
IDA: 通过直接分析推断
8387892 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
11920585 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CD70 蛋白结构

TNF

TNF: TNF(Tumour Necrosis Factor) family (74 - 191)

  • 0
  • 100
  • 193 a.a.
蛋白主名 其他名称

CD70 antigen

CD27 ligand

CD70 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CD70 P32970 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
种属内
CD70 P32970 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
种属内
CD70 P32970 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CD70 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72740 CD70 Protein, Human (HEK293, Fc) P32970 (Q45-P193) ≥95%
HY-P75387 CD70 Protein, Human (HEK293, Fc-Avi) P32970 (Q39-P193) ≥95%
HY-P78103 CD70 Trimer Protein, Human (Biotinylated, HEK293, His) P32970 (L50-P193) ≥95%
HY-P78540 FITC-Labeled CD70 Protein, Human (HEK293, His) P32970 (L50-P193) ≥95%
HY-P700035AF Animal-Free CD70 Protein, Human (His) P32970 (Q39-P193) ≥95%

关联疾病

疾病名称 别名
Lymphoproliferative Syndrome 3

LPFS3

Cd70 Deficiency

Combined Immunodeficiency Due To Cd70 Deficiency

Cid Due To Cd70 Deficiency
Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos
Lymphoproliferative Syndrome 2

Cd27 Deficiency

LPFS2

Combined Immunodeficiency Due To Cd27 Deficiency

Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency
Macroglobulinemia

Primary Macroglobulinemia

Waldenstrom Macroglobulinemia
Lymphoproliferative Syndrome

Lymphoproliferative Disorder

Lymphoproliferative Disorders

Lymphoproliferative Disorders, Susceptibility To
Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia
Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable
Immunodeficiency 20

Autosomal Recessive Primary Immunodeficiency With Defective Spontaneous Natural Killer Cell Cytotoxicity

IMD20

Autosomal Recessive Primary Immunodeficiency With Defective Spontaneous Nk Cell Cytotoxicity

Cd16 Deficiency

Immunodeficiency, Type 20
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Follicular Lymphoma

Lymphoma, Follicular

Lymphoma Follicular

Brill-Symmers' Disease

Large Cell Follicular Non-Hodgkin Lymphoma

Diffuse Follicle Centre Lymphoma

Diffuse Follicular Lymphoma Nos

Follicular Nodular Non-Hodgkin Lymphoma, Unspecified

Follicular Large Cell Cleaved Or Noncleaved Lymphoma

Large Cell Follicular Noncleaved Lymphoma

Follicular Lymphoma With Or Without Diffuse Areas

Histiocytic Follicular Lymphoma

Histiocytic Nodular Lymphoma

Histiocytic Nodular Malignant Lymphoma

Large Cell Follicular Lymphoma

Large Cell Noncleaved Follicular Lymphoma

Large Cell Noncleaved Follicular Malignant Lymphoma

Nodular Reticulum Cell Sarcoma

Noncleaved Follicular Lymphoma
Immunodeficiency 16

Combined Immunodeficiency Due To Ox40 Deficiency

IMD16

Ox40 Deficiency

Combined Immunodeficiency With Childhood-Onset Kaposi Sarcoma

Combined Immunodeficiency With Impaired Immunity To Hhv-8

Combined Immunodeficiency With Impaired Immunity To Human Herpes Virus 8

Immunodeficiency, Type 16
Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma

Hodgkin Disease

Hodgkin'S Lymphoma

Hodgkins Lymphoma

Classic Hodgkin Lymphoma

CHL

Hodgkin Lymphoma, Susceptibility To

Hl

Hodgkin'S Sarcoma

Stage I Subdiaphragmatic Hodgkin Lymphoma

Stage Ii Subdiaphragmatic Hodgkin Lymphoma

Lymphoma, Hodgkin'S

Classic Hodgkin Disease

Hodgkin'S Disease

Lymphoma, Hodgkin, Susceptibility To

Hodgkin'S Disease Of Intrapelvic Lymph Nodes

Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

Malignant Lymphogranuloma

Malignant Lymphogranulomatosis

Malignant Hodgkin Lymphoma

Classical Hodgkin Lymphoma, Type Not Specified
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos
Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-160649 MC-Gly-Gly-Phe-Gly-GABA-Exatecan Inhibitor 99.72% 否
HY-RS02264 CD70 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CD70 VGNC VGNC:38970
Macaca mulatta CD70 VGNC VGNC:70705
Mus musculus CD70 MGD MGI:1195273
Bos taurus CD70 VGNC VGNC:52225
Rattus norvegicus CD70 RGD RGD:1588573
Felis catus CD70 VGNC VGNC:60636
Macaca fascicularis CD70 NCBI NCBI:102130438
Others CD70 NCBI
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