2. 重组蛋白
  3. Cytokines and Growth Factors
  4. Chemokine & Receptors
  5. CC Chemokines
  6. CCL27
  7. CTACK/CCL27 蛋白, Human (His)

CTACK/CCL27 蛋白, Human (His)

目录号: HY-P7767A
产品使用指南

CTACK/CCL27 蛋白选择性地吸引皮肤相关记忆 T 淋巴细胞，通过 CCR10 结合介导它们归巢至皮肤部位。CCL27 对于皮肤免疫调节至关重要，以单体、二聚体和四聚体形式存在，肝素促进其寡聚化。与 TNFAIP6 的相互作用，特别是通过其 Link 结构域，意味着在皮肤微环境内的皮肤免疫反应和炎症中发挥调节作用。CTACK/CCL27 蛋白, Human (His) 是重组的 CTACK/CCL27 蛋白，由 E. coli 表达，带有 N-His 标签。

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描述

CTACK/CCL27 protein selectively attracts skin-associated memory T-lymphocytes, mediating their homing to cutaneous sites through CCR10 binding. Crucial for skin immunity regulation, CCL27 exists as a monomer, dimer, and tetramer, with heparin promoting its oligomerization. Interaction with TNFAIP6, particularly through its Link domain, implies regulatory roles in skin immune responses and inflammation within the skin microenvironment. CTACK/CCL27 Protein, Human (His) is the recombinant human-derived CTACK/CCL27 protein, expressed by E. coli , with N-His labeled tag.
研究背景

CCL27 蛋白作为一种趋化因子，专门吸引皮肤相关的记忆 T 淋巴细胞，并参与介导淋巴细胞归巢至皮肤部位。通过与 CCR10 结合，CCL27 协调皮肤中免疫细胞的迁移，表明其在皮肤免疫调节中的关键作用。该蛋白质以单体、二聚体和四聚体形式存在，肝素极力促进其寡聚化。此外，CCL27 与 TNFAIP6 相互作用，特别是通过其 Link 结构域，表明在皮肤微环境内的免疫反应和炎症过程中具有潜在的调节作用。
种属

Human
表达系统

E. coli
标签

N-His
蛋白编号

Q9Y4X3 (F25-G112)
基因 ID
蛋白结构
N-term
His
CCL27 (F25-G112)
Accession # Q9Y4X3
C-term
中文名
重组人C-C基序趋化因子27, His
同用名
rHuCCL27; C-C Motif Chemokine 27; CC Chemokine ILC; Cutaneous T-Cell-Attracting Chemokine; CTACK; Eskine; IL-11 R-Alpha-Locus Chemokine; Skinkine; Small-Inducible Cytokine A27; CCL27; ILC; SCYA27
分子量

Approximately 14 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CTACK/CCL27 Protein, Human (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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