CTACK/CCL27 蛋白, Mouse

CTACK/CCL27 protein attracts skin-associated memory T-lymphocytes, mediating lymphocyte homing to the skin. It may also participate in embryonic cell migration. Nuclear forms of CCL27 induce cytoskeletal relaxation. The protein binds to CCR10, exists in monomeric, dimeric, and tetrameric forms, and heparin promotes oligomerization. Additionally, CCL27 interacts with TNFAIP6 through its Link domain. CTACK/CCL27 Protein, Mouse is the recombinant mouse-derived CTACK/CCL27 protein, expressed by E. coli , with tag free.

CCL27 蛋白作为一种趋化因子，专门吸引皮肤相关的记忆 T 淋巴细胞，在介导淋巴细胞归巢至皮肤部位方面可能发挥至关重要的作用。该趋化因子也可能参与胚胎发生过程中的细胞迁移。值得注意的是，CCL27 的核形式可能通过诱导细胞骨架松弛来促进细胞迁移。该蛋白与 CCR10 受体结合，以单体、二聚体和四聚体形式存在，肝素强烈促进寡聚化。此外，CCL27 与 TNFAIP6 相互作用，特别是通过其 Link 结构域。

Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with mouse CCR10. The ED₅₀ for this effect is 0.02838 μg/mL, corresponding to a specific activity is 3.524×10⁴ U/mg.

Mouse

E. coli

Tag Free

Q9Z1X0-1 (L26-N120)

100039863  [NCBI]

LPLPSSTSCCTQLYRQPLPSRLLRRIVHMELQEADGDCHLQAVVLHLARRSVCVHPQNRSLARWLERQGKRLQGTVPSLNLVLQKKMYSHPQQQN

Approximately 12 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in sterile distilled water.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.