Complement Factor D/Adipsin 蛋白, Rhesus macaque (HEK293, His)

Complement Factor D/Adipsin Protein is a member of the S1, or chymotrypsin, family of serine peptidases. Complement Factor D is expressed by adipose cells, plays an important role in both physiology and pathophysiology, where it plays a regulatory role in the complement system. Complement Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Complement Factor D/Adipsin Protein, Rhesus macaque (HEK293, His) is the recombinant Rhesus Macaque-derived Complement Factor D/Adipsin protein, expressed by HEK293 , with C-His labeled tag. The total length of Complement Factor D/Adipsin Protein, Rhesus macaque (HEK293, His) is 233 a.a., with molecular weight of 70-80 kDa.

补体因子 D (CFD) 也称为 Adipsin，是丝氨酸肽酶 S1 或胰凝乳蛋白酶家族的成员。CFD由脂肪细胞表达，在补体系统中发挥调节作用，在生理学和病理生理学中发挥着重要作用。补体系统被激活作为抵御入侵病原体的第一道防线，但也参与全身炎症、血栓形成甚至自身免疫性疾病。当因子 B 与因子 C3b 复合时，CFD 会裂解因子 B，从而在补体系统的替代途径中发挥至关重要的作用。这种裂解激活 C3bbb 复合物，将其转化为替代途径的 C3 转化酶。在与经典途径中的 C1 同源的过程中，CFD 协调补体级联的激活，有助于免疫反应和宿主防御机制。其裂解活性的特异性及其参与关键补体复合物形成的作用凸显了 CFD 在调节和放大针对病原体的免疫反应中的关键作用。此外，CFD 还可调节 I 型胶原蛋白表达和成纤维细胞迁移，以增强人体肌腱修复和愈合效果^[1][2]。

Rhesus Macaque

HEK293

C-His

H9EXC1 (Q21-A253)

721138  [NCBI]

70-80 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.