1. 重组蛋白
  2. Cytokines and Growth Factors
  3. TNF Superfamily
  4. TNF Receptor Superfamily
  5. Death Receptor 6
  6. DR6/TNFRSF21 蛋白, Mouse (HEK293, His)

DR6/TNFRSF21 蛋白, Mouse (HEK293, His)

目录号: HY-P75278
产品使用指南

DR6/TNFRSF21 蛋白参与多种细胞过程,并通过 NF-kappa-B 激活、BAX 介导的途径和细胞色素 c 释放促进细胞凋亡。它对于神经元凋亡至关重要,特别是对 APP 衍生的淀粉样肽的反应,并且对于正常细胞体死亡和轴突修剪也至关重要。DR6/TNFRSF21 蛋白, Mouse (HEK293, His) 是重组的 DR6/TNFRSF21 蛋白,由 HEK293 表达,带有 C-His 标签。

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描述

The DR6/TNFRSF21 protein participates in multiple cellular processes and promotes apoptosis through NF-kappa-B activation, BAX-mediated pathways, and cytochrome c release. It is critical for neuronal apoptosis, particularly in response to APP-derived amyloid peptides, and is critical for normal cell body death and axonal pruning. DR6/TNFRSF21 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DR6/TNFRSF21 protein, expressed by HEK293 , with C-His labeled tag.

研究背景

DR6/TNFRSF21 蛋白参与多种细胞过程。它通过多种途径促进细胞凋亡,包括激活 NF-kappa-B、BAX 介导的细胞凋亡以及线粒体释放细胞色素 c。它在神经元凋亡中发挥着至关重要的作用,特别是在对 APP 衍生的淀粉样肽的反应中,并且对于正常细胞体死亡和轴突修剪至关重要。此外,它还对少突胶质细胞的存活、成熟和髓鞘形成产生负面影响。在适应性免疫反应中,它参与 T 细胞受体触发的信号级联,影响 T 细胞分化、增殖和细胞因子释放。此外,它还能抑制 T 细胞刺激后的 JNK 激活,并负向调节针对抗原的 IgG、IgM 和 IgM 的产生。它还充当细胞焦亡的调节剂,招募 CASP8 以响应活性氧和氧化,从而导致 GSDMC 激活。DR6/TNFRSF21 蛋白与 NGFR、CASP8 和 N-APP 相互作用,并与 TRADD 结合。

种属

Mouse

表达系统

HEK293

标签

C-His

蛋白编号

Q9EPU5 (Q42-H349)

基因 ID
蛋白结构
N-term
DR6 (Q42-H349)
Accession # Q9EPU5
His
C-term
同用名
Tumor necrosis factor receptor superfamily member 21; CD358; Tnfrsf21; DR6
分子量

55-60 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

DR6/TNFRSF21 Protein, Mouse (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
DR6/TNFRSF21 Protein, Mouse (HEK293, His)
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HY-P75278
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