Fumarylacetoacetase/FAH 蛋白, Human (HEK293, His)

Fumarylacetoacetase/FAH Protein is a key enzyme in the metabolism of phenylalanine and tyrosine expressed primarily in the liver. Deficiency of FAH causes hereditary tyrosinemia type 1. Fumarylacetoacetase/FAH Protein, Human (HEK293, His) is the recombinant human-derived Fumarylacetoacetase/FAH protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Fumarylacetoacetase/FAH Protein, Human (HEK293, His) is 418 a.a., with molecular weight of ~43.0 kDa.

Fumarylacetoacetase 是一种由人类第 15 号染色体上的 FAH 基因编码的酶。FAH 基因被认为与人体苯丙氨酸的分解代谢有关，是一种主要在肝脏中表达的苯丙氨酸和酪氨酸代谢的关键酶。FAH 是一种蛋白质同型二聚体，在水解反应中裂解富马酰乙酸的碳-碳键。FAH 的活性位点含有 Ca²⁺。FAH 的缺乏会引起 1 型遗传性酪氨酸血症。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

HEK293

C-6*His

P16930-1 (S2-S419)

2184  [NCBI]

SFIPVAEDSDFPIHNLPYGVFSTRGDPRPRIGVAIGDQILDLSIIKHLFTGPVLSKHQDVFNQPTLNSFMGLGQAAWKEARVFLQNLLSVSQARLRDDTELRKCAFISQASATMHLPATIGDYTDFYSSRQHATNVGIMFRDKENALMPNWLHLPVGYHGRASSVVVSGTPIRRPMGQMKPDDSKPPVYGACKLLDMELEMAFFVGPGNRLGEPIPISKAHEHIFGMVLMNDWSARDIQKWEYVPLGPFLGKSFGTTVSPWVVPMDALMPFAVPNPKQDPRPLPYLCHDEPYTFDINLSVNLKGEGMSQAATICKSNFKYMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGPEPENFGSMLELSWKGTKPIDLGNGQTRKFLLDGDEVIITGYCQGDGYRIGFGQCAGKVLPALLPS

Approximately 43.0 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.5.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.