GBP1 蛋白, Human (HEK293, His)

GBP1 Protein belongs to the dynamin superfamily of large GTPases. GBP1 plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. It hydrolyzes GTP to GMP in two consecutive cleavage reactions. GBP1 also acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria. In addition, it exhibits antiviral activity against influenza virus. GBP1 Protein, Human (HEK293, His) is the recombinant human-derived GBP1 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of GBP1 Protein, Human (HEK293, His) is 589 a.a., with molecular weight of ~65 kDa.

鸟苷酸结合蛋白 1 (GBP1) 属于大 GTP 酶的动力超家族。GBP1 在针对多种细菌、病毒和原生动物病原体的先天免疫中发挥着重要作用。它通过两个连续的裂解反应将 GTP 水解为 GMP: GTP 首先水解为 GDP，然后以连续方式水解为 GMP。感染后，GBP1 被招募到含有病原体的液泡或液泡逃逸细菌中，并促进自噬和炎性小体组装。GBP1 还通过促进细菌释放炎症小体配体，充当炎症小体组装的正调节因子。GBP1 为多种病原体提供保护，包括细菌病原体 单核细胞增生李斯特氏菌 和 牛分枝杆菌 BCG 以及原生动物病原体弓形虫。此外，它还具有针对流感病毒的抗病毒活性^[1][2]。

Human

HEK293

C-10*His

AAA35871.1 (M1-C589)

2633  [NCBI]

Approximately 65 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.