2. Gene
  3. GBP1 - guanylate binding protein 1 Gene

GBP1 - guanylate binding protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：鸟苷酸结合蛋白 1

种属: Homo sapiens

基因 ID: 2633 | 基因类型: protein coding

关于 GBP1

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,052,319-89,065,208 (from NCBI)

This gene has 9 transcripts (splice variants), 134 orthologues and 10 paralogues. Broad expression in appendix (RPKM 60.1), lymph node (RPKM 37.4) and 24 other tissues.

功能概要

干扰素诱导鸟苷酸结合蛋白表达。鸟苷酸结合蛋白的特点是它们能够特异性结合鸟嘌呤核苷酸 (GMP、GDP 和 GTP) ，并且与 GTP 结合蛋白的区别在于存在 2 个结合基序而不是 3 个。[RefSeq 提供，2008 年 7 月]

Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]

GBP1 基因产物(1)

mRNA Protein Name
NM_002053.3 NP_002044.2 guanylate-binding protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein activity IDA
IDA: 通过直接分析推断
7512561 GOA
enables GDP binding IDA
IDA: 通过直接分析推断
10676968 GOA
enables GDP phosphatase activity IDA
IDA: 通过直接分析推断
7512561 GOA
enables GTP binding IDA
IDA: 通过直接分析推断
10676968 GOA
enables GTPase activity IDA
IDA: 通过直接分析推断
7512561 GOA
enables Hsp90 protein binding IPI
IPI: 通过物理相互作用推断
24337748 GOA
enables actin binding IDA
IDA: 通过直接分析推断
24337748 GOA
enables cytokine binding IPI
IPI: 通过物理相互作用推断
24337748 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
24337748 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16511497 GOA
enables lipopolysaccharide binding IDA
IDA: 通过直接分析推断
32510692 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21151871 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
10676968 GOA
enables spectrin binding IPI
IPI: 通过物理相互作用推断
24337748 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to interleukin-1 IEP
IEP: 通过表达模式推断
17266443 GOA
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
17266443 GOA
involved in cellular response to type II interferon IDA
IDA: 通过直接分析推断
17266443 GOA
involved in cytolysis in another organism IDA
IDA: 通过直接分析推断
31268602 GOA
involved in defense response to bacterium IDA
IDA: 通过直接分析推断
31268602 GOA
involved in defense response to protozoan IDA
IDA: 通过直接分析推断
31268602 GOA
involved in innate immune response IDA
IDA: 通过直接分析推断
29144452 GOA
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
24337748 GOA
involved in negative regulation of T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
24337748 GOA
involved in negative regulation of interleukin-2 production IMP
IMP: 通过突变表型推断
24337748 GOA
involved in negative regulation of protein localization to plasma membrane IMP
IMP: 通过突变表型推断
24337748 GOA
involved in negative regulation of substrate adhesion-dependent cell spreading IMP
IMP: 通过突变表型推断
24337748 GOA
involved in non-canonical inflammasome complex assembly IDA
IDA: 通过直接分析推断
31268602 GOA
involved in positive regulation of pyroptotic inflammatory response IDA
IDA: 通过直接分析推断
31268602 GOA
involved in protein localization to vacuole IDA
IDA: 通过直接分析推断
21151871 GOA
involved in regulation of calcium-mediated signaling IMP
IMP: 通过突变表型推断
24337748 GOA
involved in regulation of protein localization to plasma membrane IGI
IGI: 通过遗传相互作用推断
24337748 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
17266443 GOA
located in actin cytoskeleton IDA
IDA: 通过直接分析推断
21151871 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
17266443 GOA
is active in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
29144452 GOA
located in cytosol IDA
IDA: 通过直接分析推断
24337748 GOA
is active in symbiont cell surface IDA
IDA: 通过直接分析推断
29144452 GOA
is active in vesicle membrane IDA
IDA: 通过直接分析推断
29144452 GOA
located in vesicle membrane IDA
IDA: 通过直接分析推断
21151871 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GBP1 蛋白结构

GBP

GBP: Guanylate-binding protein, N-terminal domain (19 - 282)

GBP_C

GBP_C: Guanylate-binding protein, C-terminal domain (284 - 580)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 592 a.a.
蛋白主名 其他名称

guanylate-binding protein 1

GBP-1

重组 GBP1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75172 GBP1 Protein, Human (HEK293, His) AAA35871.1 (M1-C589) ≥95%

关联疾病

疾病名称 别名
Pseudopseudohypoparathyroidism

PPHP

Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance

Normocalcemic Pseudohypoparathyroidism

Aho-Pphp Syndrome

Albright Hereditary Osteodystrophy-Pphp Syndrome

Pseudohypoparathyroidism
Ulceroglandular Tularemia
Congenital Toxoplasmosis

Toxoplasmosis, Congenital

Mother-To-Child Transmission Of Toxoplasmosis

Toxoplasma Embryofetopathy

Toxoplasma Embryopathy

Toxoplasmosis - Congen.

Toxoplasmosis Congenital
Central Nervous System Tuberculosis

Intracranial Tuberculoma

Tuberculoma Of Brain

Tuberculosis Of Meninges And Central Nervous System

Tuberculous Abscess Of Brain

Tuberculoma, Intracranial

Tuberculosis, Central Nervous System
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12929 NSC756093 Inhibitor 99.86% 否
HY-RS05307 GBP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus GBP1 RGD RGD:1311877
Others GBP1 NCBI
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